Centro de Investigación Biomédica Del Sur, Instituto Mexicano Del Seguro Social, Xochitepec, Morelos, Mexico; Centro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional, Yautepec, Morelos, Mexico.
Centro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional, Yautepec, Morelos, Mexico.
J Ethnopharmacol. 2024 Dec 5;335:118624. doi: 10.1016/j.jep.2024.118624. Epub 2024 Jul 24.
Passiflora coriacea Juss., a medicinal plant in the family Passifloraceae, is widely used to treat anxiety and depression in Mexican folk medicine. However, its chemical profile and biological activity have not been characterized.
The aim of the study was to determine the antidepressant activity, anxiolytic effect, and chemical profile of Passiflora coriacea.
An organic fraction (PcEA) from a hydroalcoholic extract of the aerial parts of P. coriacea was obtained, followed by a chemical analysis and separation, yielding six fractions (PcEA, T1, T2, T1.1, T2.1, and T2.2). Male ICR mice were used to determine the antidepressant activity of selected treatments (PcEA, T1, T2, and T1.1) based on a forced swim test (FST). The anxiolytic-like effects of various treatments (PcEA, T1, T2, T2.1, and T2.2) were determined using the elevated plus maze (EPM) test.
The organic fraction of P. coriacea decreased anxiety-like behaviors in mice and increased the time of mobility in the FST. After chemical separation, two compounds were isolated from the species with antidepressant activity and anxiolytic-like effects, T1.1 (tricin 7-O-glucoside) and T2.2 (harmane), respectively.
Compounds isolated from P. coriacea exerted anxiolytic and antidepressant effects in mice based on the EPM and FST. The flavonoid tricin-7-O-glucoside and the alkaloid harmane contributed to these biological activities.
西番莲科植物西番莲，是一种被广泛应用于治疗焦虑和抑郁的传统药物。然而，其化学成分和生物活性尚未被完全阐明。
本研究旨在确定西番莲的抗抑郁活性、抗焦虑作用及其化学成分。
从西番莲地上部分的水醇提取物中获得有机部分（PcEA），然后进行化学分析和分离，得到六个部分（PcEA、T1、T2、T1.1、T2.1 和 T2.2）。雄性 ICR 小鼠用于通过强迫游泳试验（FST）确定选定治疗方法（PcEA、T1、T2 和 T1.1）的抗抑郁活性。通过高架十字迷宫（EPM）试验确定各种治疗方法（PcEA、T1、T2、T2.1 和 T2.2）的抗焦虑样作用。
西番莲的有机部分可降低小鼠的焦虑样行为，并增加 FST 中的活动时间。经过化学分离，从该物种中分离出两种具有抗抑郁和抗焦虑样作用的化合物，T1.1（tricetin 7-O-glucoside）和 T2.2（harmane）。
从西番莲中分离出的化合物在 EPM 和 FST 中表现出抗焦虑和抗抑郁作用。类黄酮tricetin-7-O-glucoside 和生物碱 harmane 对这些生物活性有贡献。
