Aricioglu Feyza, Altunbas Hale
Department of Pharmacology, Faculty of Pharmacy, Marmara University, Haydarpasa, Istanbul, Turkey.
Ann N Y Acad Sci. 2003 Dec;1009:196-201. doi: 10.1196/annals.1304.024.
A forced swim test (FST) and an elevated plus maze (EPM) were used to determine antidepressant and anxiolytic effects of harmane in rats in comparison with a known antidepressant, imipramine (30 mg/kg i.p.). Harmane (2.5, 5.0, or 10 mg/kg, i.p.), saline, or imipramine were given 30 minutes before the tests. Administration of harmane decreased the time of immobility in the FST dose-dependently and increased the time spent in open arms in the EPM, as compared with the saline group. As an endogenous substance, harmane therefore has anti-anxiety and antidepressant effects.
采用强迫游泳试验（FST）和高架十字迷宫（EPM），与已知抗抑郁药丙咪嗪（腹腔注射30mg/kg）相比，测定哈尔满对大鼠的抗抑郁和抗焦虑作用。在试验前30分钟给予哈尔满（腹腔注射2.5、5.0或10mg/kg）、生理盐水或丙咪嗪。与生理盐水组相比，给予哈尔满可剂量依赖性地减少FST中的不动时间，并增加EPM中在开放臂的停留时间。因此，作为一种内源性物质，哈尔满具有抗焦虑和抗抑郁作用。
