[醋酸卤泼尼龙的致突变性试验]

[Mutagenicity test of halopredone acetate].

作者信息

Ohuchida A, Yoshida R, Morita K

出版信息

J Toxicol Sci. 1985 Aug;10 Suppl 1:123-8. doi: 10.2131/jts.10.supplementi_123.

DOI:10.2131/jts.10.supplementi_123

Abstract

The mutagenicity of halopredone acetate (THS-201) was investigated by means of reverse mutation test in seven bacterial strains (S. typhimurium TA100, TA1535, TA98, TA1538, TA1537 and E. coli WP2, WP2 uvrA) and chromosomal aberration test in cultured Chinese hamster cells (CHL). In the reverse mutation test, no significant increase of revertant was observed at dose levels from 50 to 5000 micrograms/plate in the absence and presence of mammalian metabolic activation system. THS-201 caused no increase of chromosomal aberrants at dose levels of 1.6, 8.0, 40.0 and 200 micrograms/ml irrespective of metabolic activation. These results indicated that THS-201 has no mutagenic activity.

摘要

通过在七种细菌菌株（鼠伤寒沙门氏菌TA100、TA1535、TA98、TA1538、TA1537以及大肠杆菌WP2、WP2 uvrA）中进行回复突变试验，以及在培养的中国仓鼠细胞（CHL）中进行染色体畸变试验，对醋酸卤泼尼龙（THS - 201）的致突变性进行了研究。在回复突变试验中，无论有无哺乳动物代谢激活系统，在50至5000微克/平板的剂量水平下均未观察到回复突变体的显著增加。无论有无代谢激活，THS - 201在1.6、8.0、40.0和200微克/毫升的剂量水平下均未导致染色体畸变增加。这些结果表明，THS - 201没有致突变活性。