Lin Jiechun, Han Yingxiang, Liu Meng, Wang Xiaofei
School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325035, China.
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.
Bioengineering (Basel). 2024 Jul 5;11(7):684. doi: 10.3390/bioengineering11070684.
Previous studies have indicated an association between education and myopia, suggesting that numerous stress events during the educational process may influence eye health. This study aimed to investigate the impact of mental stress induced by mental arithmetic (MA) on choroidal thickness (CT). This study included 33 participants aged between 19 and 29 years. Swept-source optical coherence tomography (SS-OCT) was used to capture images of the posterior segment of the left eye during baseline and MA to assess changes in the CT. After denoising and compensation, the baseline images and MA images that had been rigidly registered and resampled to the baseline images were segmented using a deep learning-based method. Based on the segmentation results, the CT within the regions of 1 mm and 3 mm diameter centered at the lowest point of the fovea was calculated. Significant increases were observed in both CT and CT during MA, with mean changes of 2.742 ± 7.098 μm ( = 0.034) and 3.326 ± 6.143 μm ( < 0.001), respectively. Thickening of the choroid has been observed during acute mental stress. We speculate that long-term or chronic mental stress could have a potential adverse impact on myopia progression.
以往的研究表明教育与近视之间存在关联，这表明教育过程中的众多压力事件可能会影响眼睛健康。本研究旨在调查心算（MA）诱发的精神压力对脉络膜厚度（CT）的影响。本研究纳入了33名年龄在19至29岁之间的参与者。使用扫频光学相干断层扫描（SS-OCT）在基线期和心算期间采集左眼后段图像，以评估脉络膜厚度的变化。在去噪和补偿后，使用基于深度学习的方法对已与基线图像进行刚性配准和重采样的基线图像和心算图像进行分割。根据分割结果，计算以中央凹最低点为中心、直径为1毫米和3毫米区域内的脉络膜厚度。在心算期间，脉络膜厚度和脉络膜厚度均显著增加，平均变化分别为2.742±7.098μm（P = 0.034）和3.326±6.143μm（P < 0.001）。在急性精神压力期间观察到脉络膜增厚。我们推测长期或慢性精神压力可能对近视进展产生潜在的不利影响。
