Department of Hematology, University of Health Sciences, Okmeydanı Training and Research Hospital, Istanbul, Turkey,
Department of Hematology, University of Health Sciences, Istanbul Training and Research Hospital, Istanbul, Turkey.
Med Princ Pract. 2021;30(1):69-72. doi: 10.1159/000508981. Epub 2020 May 27.
We aimed to investigate whether the severity of fatigue and the incidences of depression and anxiety of patients with beta thalassemia minor (BTm) are different from healthy individuals using the Fatigue Severity Scale (FSS) and Hospital Anxiety and Depression Scale (HADS).
BTm patients who were followed at the University of Health Sciences Istanbul Training and Research Hospital Hematology Clinic between 2016 and 2017 and who had normal biochemical parameters, thyroid function tests and C-reactive protein levels, and did not use any medications, consume alcohol or tobacco, have any chronic diseases or sleep disturbances were included in the study. Healthy control subjects who were matched with age, sex, marital status, educational status, and body mass index (BMI) were also included for comparison.
Thirty-nine BTm patients and 25 healthy controls were included in the study. The BTm and the control groups were comparable in terms of gender, age, BMI, educational status and marital status (p = 0.368, 0.755, 0.851, 0.785, and 0.709, respectively). FSS score was ≥4 in 23 (59.0%) BTm subjects and in 15 (60%) control subjects (p = 1.0). HADS anxiety score was ≥10 in 20 (51.3%) BTm subjects and in 5 (20.0%) control subjects (p = 0.018), and HADS depression score was ≥7 in 20 (51.3%) BTm subjects and in 6 (24.0%) healthy control subjects (p = 0.039).There was no correlation of hemoglobin with FSS score (p = 0.526, r = -0.105), HADS anxiety score (p = 0.703, r = -0.063), or HADS depression score (p = 0.718, r = -0.06) in the BTm group.
We found that both depression and anxiety were higher in BTm patients than in healthy individuals, but this difference was not feasible for fatigue.
我们旨在使用疲劳严重程度量表（FSS）和医院焦虑抑郁量表（HADS），调查β地中海贫血微量（BTm）患者的疲劳严重程度以及抑郁和焦虑发生率是否与健康个体存在差异。
本研究纳入了 2016 年至 2017 年在伊斯坦布尔健康科学大学培训与研究医院血液科就诊，且生化参数、甲状腺功能检查和 C 反应蛋白水平正常、未使用任何药物、饮酒或吸烟、无任何慢性疾病或睡眠障碍的 BTm 患者，并纳入了年龄、性别、婚姻状况、教育程度和体重指数（BMI）相匹配的健康对照组进行比较。
本研究共纳入 39 例 BTm 患者和 25 例健康对照组。BTm 组和对照组在性别、年龄、BMI、教育程度和婚姻状况方面无差异（p = 0.368、0.755、0.851、0.785 和 0.709）。23 例（59.0%）BTm 患者和 15 例（60.0%）对照组的 FSS 评分≥4（p = 1.0）。20 例（51.3%）BTm 患者和 5 例（20.0%）对照组的 HADS 焦虑评分≥10（p = 0.018），20 例（51.3%）BTm 患者和 6 例（24.0%）健康对照组的 HADS 抑郁评分≥7（p = 0.039）。BTm 组中血红蛋白与 FSS 评分（p = 0.526，r = -0.105）、HADS 焦虑评分（p = 0.703，r = -0.063）或 HADS 抑郁评分（p = 0.718，r = -0.06）均无相关性。
我们发现，BTm 患者的抑郁和焦虑发生率高于健康个体，但这一差异在疲劳方面并不明显。
