Department of Ecological and Biological Sciences (DEB), University of Tuscia, 01100 Viterbo, Italy.
Department for Innovation in Biological, Agro-Food and Forest Systems (DIBAF), University of Tuscia, 01100 Viterbo, Italy.
Biomolecules. 2024 Jul 15;14(7):855. doi: 10.3390/biom14070855.
Alzheimer's disease (AD) brains are histologically marked by the presence of intracellular and extracellular amyloid deposits, which characterize the onset of the disease pathogenesis. Increasing evidence suggests that certain nutrients exert a direct or indirect effect on amyloid β (Aβ)-peptide production and accumulation and, consequently, on AD pathogenesis. We exploited the fruit fly model of AD to evaluate in vivo the beneficial properties of Lisosan G, a fermented powder obtained from organic whole grains, on the intracellular Aβ-42 peptide accumulation and related pathological phenotypes of AD. Our data showed that the Lisosan G-enriched diet attenuates the production of neurotoxic Aβ peptides in fly brains and reduces neuronal apoptosis. Notably, Lisosan G exerted anti-oxidant effects, lowering brain levels of reactive oxygen species and enhancing mitochondrial activity. These aspects paralleled the increase in autophagy turnover and the inhibition of nucleolar stress. Our results give support to the use of the Drosophila model not only to investigate the molecular genetic bases of neurodegenerative disease but also to rapidly and reliably test the efficiency of potential therapeutic agents and diet regimens.
阿尔茨海默病（AD）的大脑在组织学上以细胞内和细胞外淀粉样沉积的存在为特征，这标志着疾病发病机制的开始。越来越多的证据表明，某些营养素对淀粉样 β（Aβ）-肽的产生和积累有直接或间接的影响，进而对 AD 的发病机制有影响。我们利用 AD 果蝇模型评估了 Lisosan G（一种从有机全谷物中提取的发酵粉）在体内对 Aβ-42 肽积累和相关 AD 病理表型的有益特性。我们的数据表明，富含 Lisosan G 的饮食可以减轻果蝇大脑中神经毒性 Aβ肽的产生并减少神经元凋亡。值得注意的是，Lisosan G 发挥了抗氧化作用，降低了大脑中活性氧的水平并增强了线粒体的活性。这些方面与自噬周转率的增加和核仁应激的抑制相平行。我们的研究结果支持使用果蝇模型不仅可以研究神经退行性疾病的分子遗传基础，还可以快速可靠地测试潜在治疗剂和饮食方案的效率。
