Laboratory of Natural Products & Drug Discovery, Center CEBIM, Department of Basic Sciences, Faculty of Medicine, Universidad de La Frontera, Temuco 4780000, Chile.
Department of Chemistry and Industrial Chemistry, Kwara State University, Malete 1530, Nigeria.
Biomolecules. 2024 Jul 19;14(7):867. doi: 10.3390/biom14070867.
Chemotherapeutic drugs and radiotherapy are fundamental treatments to combat cancer, but, often, the doses in these treatments are restricted by their non-selective toxicities, which affect healthy tissues surrounding tumors. On the other hand, drug resistance is recognized as the main cause of chemotherapeutic treatment failure. Rosmarinic acid (RA) is a polyphenol of the phenylpropanoid family that is widely distributed in plants and vegetables, including medicinal aromatic herbs, consumption of which has demonstrated beneficial activities as antioxidants and anti-inflammatories and reduced the risks of cancers. Recently, several studies have shown that RA is able to reverse cancer resistance to first-line chemotherapeutics, as well as play a protective role against toxicity induced by chemotherapy and radiotherapy, mainly due to its scavenger capacity. This review compiles information from 56 articles from Google Scholar, PubMed, and ClinicalTrials.gov aimed at addressing the role of RA as a complementary therapy in cancer treatment.
化疗药物和放射疗法是对抗癌症的基本治疗方法，但这些治疗方法的剂量常常受到其非选择性毒性的限制，这些毒性会影响肿瘤周围的健康组织。另一方面，药物耐药性被认为是化疗治疗失败的主要原因。迷迭香酸（RA）是苯丙烷类多酚的一种，广泛分布于植物和蔬菜中，包括药用芳香草药，其消费已被证明具有抗氧化和抗炎作用，并降低了癌症的风险。最近，有几项研究表明，RA 能够逆转癌症对一线化疗药物的耐药性，并在化疗和放疗引起的毒性方面发挥保护作用，主要是由于其清除能力。这篇综述从 Google Scholar、PubMed 和 ClinicalTrials.gov 中汇集了 56 篇文章的信息，旨在探讨 RA 作为癌症治疗辅助疗法的作用。
