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体外培养物水提取物的植物化学特征、抗氧化能力及抗癌潜力

Phytochemical Profile, Antioxidant Capacity and Anticancer Potential of Water Extracts from In Vitro Cultivated .

作者信息

Tasheva Krasimira, Sulikovska Inna, Georgieva Ani, Djeliova Vera, Lozanova Vesela, Vasileva Anelia, Ivanov Ivaylo, Denev Petko, Lazarova Maria, Vassileva Valya, Petkova-Kirova Polina

机构信息

Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113 Sofia, Bulgaria.

Department of Pathology, Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

出版信息

Molecules. 2025 Mar 23;30(7):1427. doi: 10.3390/molecules30071427.

DOI:10.3390/molecules30071427
PMID:40286005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11990555/
Abstract

L. (Mediterranean sage) is a medicinal plant known for its rich phenolic content and different therapeutic properties. This study evaluated the phytochemical composition, antioxidant capacity and anticancer potential of water extracts from in vitro cultivated . The extract exhibited a high total polyphenol (110.03 ± 0.7 mg GAE/g) and flavonoid (7.88 ± 0.25 mg QE/g) content, along with a strong oxygen radical absorbance capacity (an ORAC value of 3677.9 ± 24.8 µmol TE/g). LC-HRMS analysis identified 21 bioactive compounds, including salvianic acid C, rosmarinic acid, salvianolic acid K and various organic acids. A cytotoxicity evaluation using the Neutral Red Uptake assay showed that the extract had a low toxicity to non-cancerous BALB/3T3 cells. An antiproliferative activity assessment via the MTT assay revealed selective cytotoxicity against Hep G2 hepatocellular carcinoma cells (IC = 353.8 ± 21.8 µg/mL) and lung (A549) and prostate (PC-3) carcinoma cell lines. Migration assays and cytopathological evaluations confirmed the significant inhibition of cancer cell proliferation, the suppression of migration and G2/M cell cycle arrest. Flow cytometry revealed considerable increases in apoptotic and necrotic cell populations following treatment with extract. These findings showed the potential of as a promising source of bioactive compounds with antioxidant and anticancer properties, supporting its further exploration for therapeutic applications.

摘要

迷迭香叶（地中海鼠尾草）是一种药用植物，以其丰富的酚类成分和多种治疗特性而闻名。本研究评估了体外培养的迷迭香叶水提取物的植物化学成分、抗氧化能力和抗癌潜力。该提取物表现出较高的总多酚含量（110.03±0.7毫克没食子酸当量/克）和黄酮类化合物含量（7.88±0.25毫克槲皮素当量/克），以及较强的氧自由基吸收能力（氧自由基吸收能力值为3677.9±24.8微摩尔 Trolox 当量/克）。液相色谱-高分辨质谱分析鉴定出21种生物活性化合物，包括丹酚酸C、迷迭香酸、丹酚酸K和各种有机酸。使用中性红摄取试验进行的细胞毒性评估表明，该提取物对非癌性BALB/3T3细胞毒性较低。通过MTT试验进行的抗增殖活性评估显示，该提取物对Hep G2肝癌细胞（半数抑制浓度=353.8±21.8微克/毫升）以及肺癌（A549）和前列腺癌（PC-3）细胞系具有选择性细胞毒性。迁移试验和细胞病理学评估证实了癌细胞增殖受到显著抑制、迁移受到抑制以及G2/M期细胞周期阻滞。流式细胞术显示，用该提取物处理后，凋亡和坏死细胞群体显著增加。这些发现表明，迷迭香叶有潜力成为具有抗氧化和抗癌特性的生物活性化合物的理想来源，支持对其进行进一步的治疗应用探索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/c89eed74267c/molecules-30-01427-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/866356c7238f/molecules-30-01427-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/f6c6881ef84d/molecules-30-01427-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/608b08339265/molecules-30-01427-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/e52e326f4dd9/molecules-30-01427-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/8ba927c50ed4/molecules-30-01427-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/c8ba6f08bc93/molecules-30-01427-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/c89eed74267c/molecules-30-01427-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/866356c7238f/molecules-30-01427-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/f6c6881ef84d/molecules-30-01427-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/608b08339265/molecules-30-01427-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/e52e326f4dd9/molecules-30-01427-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/8ba927c50ed4/molecules-30-01427-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/c8ba6f08bc93/molecules-30-01427-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3437/11990555/c89eed74267c/molecules-30-01427-g007.jpg

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