Hainan Academy of Medical Sciences, School of Pharmacy, Hainan Medical University, Haikou 571199, China.
Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou 571199, China.
Int J Mol Sci. 2024 Jul 10;25(14):7560. doi: 10.3390/ijms25147560.
The muscarinic acetylcholine receptor M (M-mAChR) is involved in various physiological and pathological processes. Owing to specific cardioprotective effects, M-mAChR is an ideal diagnostic and therapeutic biomarker for cardiovascular diseases (CVDs). Growing evidence has linked M-mAChR to the development of multiple CVDs, in which it plays a role in cardiac protection such as anti-arrhythmia, anti-hypertrophy, and anti-fibrosis. This review summarizes M-mAChR's expression patterns, functions, and underlying mechanisms of action in CVDs, especially in ischemia/reperfusion injury, cardiac hypertrophy, and heart failure, opening up a new research direction for the treatment of CVDs.
毒蕈碱型乙酰胆碱受体 M（M-mAChR）参与多种生理和病理过程。由于具有特定的心脏保护作用，M-mAChR 是心血管疾病（CVDs）的理想诊断和治疗生物标志物。越来越多的证据表明，M-mAChR 与多种 CVDs 的发展有关，在这些疾病中，它在抗心律失常、抗肥大和抗纤维化等心脏保护中发挥作用。本综述总结了 M-mAChR 在 CVDs 中的表达模式、功能及其作用机制，特别是在缺血/再灌注损伤、心肌肥厚和心力衰竭中的作用，为 CVDs 的治疗开辟了新的研究方向。
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