Uthra Chandrabose, Nagaraj Karuppiah, Wadaan Mohammad Ahmad, Karuppiah Chelladurai, Maity Prasenjit, Baabbad Almohannad, Kaliyaperumal Raja, Venkatachalapathy Renuka, Shah Flora, Kumar Puneet
Department of Microbiology, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu, India.
School of Pharmacy, National Forensic Sciences University, 6M56+XP8, Police Bhavan Rd, Sector 9, Gandhinagar 382007, Gujarat, India.
Materials (Basel). 2024 Jul 12;17(14):3444. doi: 10.3390/ma17143444.
This study explores the challenge of antimicrobial resistance by investigating the utilization of zinc oxide (ZnO) and copper oxide (CuO) nanoparticles (NPs) to combat antibiotic-resistant bacteria in wastewater treatment plants (WWTPs). The synthesized metal oxide NPs underwent thorough characterization through various analytical techniques, confirming their nanoparticulate nature. Electronic absorption and X-ray diffraction (XRD) analyses revealed successful reduction processes and crystalline properties, respectively. Fourier transform infrared spectroscopy (FTIR) results indicated the stabilization of nanoparticles in solution. Scanning electron microscopy (SEM) observations revealed well-defined spherical and flower-like morphologies for the zinc and copper oxide nanoparticles, with sizes approximately ranging from 50 nm to 25 nm Notably, the synthesized nanoparticles exhibited heightened efficacy in impeding biofilm formation, with zinc oxide NPs displaying superior antibacterial activity compared to copper. These findings suggest the promising potential of these nanoparticles in controlling antibiotic-resistant organisms, even following WWTP treatment processes. This research contributes to the ongoing advancements in nanotechnology aimed at combating antibiotic resistance, offering new prospects for the development of effective wastewater treatment strategies.
本研究通过调查利用氧化锌（ZnO）和氧化铜（CuO）纳米颗粒（NPs）来对抗污水处理厂（WWTPs）中的抗生素抗性细菌，探讨了抗生素耐药性的挑战。通过各种分析技术对合成的金属氧化物纳米颗粒进行了全面表征，证实了它们的纳米颗粒性质。电子吸收和X射线衍射（XRD）分析分别揭示了成功的还原过程和晶体性质。傅里叶变换红外光谱（FTIR）结果表明纳米颗粒在溶液中稳定。扫描电子显微镜（SEM）观察显示氧化锌和氧化铜纳米颗粒具有明确的球形和花状形态，尺寸约为50纳米至25纳米。值得注意的是，合成的纳米颗粒在阻碍生物膜形成方面表现出更高的功效，氧化锌纳米颗粒比铜表现出更强的抗菌活性。这些发现表明，即使经过污水处理厂的处理过程，这些纳米颗粒在控制抗生素抗性生物方面也具有广阔的潜力。本研究为旨在对抗抗生素耐药性的纳米技术的不断进步做出了贡献，为开发有效的废水处理策略提供了新的前景。
