Panpetch Jittraporn, Kiatrungrit Komsan, Tuntipopipat Siriporn, Tangphatsornruang Sithichoke, Mhuantong Wuttichai, Chongviriyaphan Nalinee
Doctoral Program in Nutrition, Faculty of Medicine Ramathibodi Hospital and Institute of Nutrition, Mahidol University, Bangkok 10400, Thailand.
Department of Psychiatry, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
J Pers Med. 2024 Jul 10;14(7):739. doi: 10.3390/jpm14070739.
Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder potentially linked to gut dysbiosis. This comparative cross-sectional study profiled the gut microbiota in 24 treatment-naïve Thai children diagnosed with ADHD and 24 healthy ones matched by age and gender (median age: 7 years). Fecal microbial compositions were genetically analyzed using 16s rRNA gene amplicon sequencing. The study findings indicated no statistically significant differences in microbial diversity between groups, although Firmicutes and Actinobacteria appeared dominant in both groups. Moreover, ADHD patients exhibited enrichment in , , , and genera, while healthy controls had higher levels of , , , and genera. Spearman correlation analysis demonstrated a significant positive association between and inattention and hyperactivity/impulsivity scores, whereas the group and exhibited negative correlations with these symptomatology domains. Beta-carotene intake was associated with the group and : likewise, vitamin B2 intake was associated with . Additional research should aim to elucidate the underlying mechanisms influencing clinical biomarkers that signify alterations in specific gut microbiome profiles linked to ADHD.
注意力缺陷多动障碍（ADHD）是一种可能与肠道菌群失调有关的神经发育障碍。这项比较性横断面研究对24名未经治疗的泰国ADHD确诊儿童和24名年龄及性别匹配的健康儿童（中位年龄：7岁）的肠道微生物群进行了分析。使用16S rRNA基因扩增子测序对粪便微生物组成进行了基因分析。研究结果表明，两组之间的微生物多样性在统计学上没有显著差异，尽管厚壁菌门和放线菌门在两组中似乎都占主导地位。此外，ADHD患者在某些属中表现出富集，而健康对照组在某些属中的水平较高。Spearman相关性分析表明，某菌属与注意力不集中和多动/冲动评分之间存在显著正相关，而另一菌属组与这些症状领域呈负相关。β-胡萝卜素的摄入量与某菌属组有关，同样，维生素B2的摄入量与另一菌属有关。进一步的研究应旨在阐明影响临床生物标志物的潜在机制，这些生物标志物表明与ADHD相关的特定肠道微生物群谱的改变。 （注：原文中部分属名未给出具体内容，用“某菌属”等表示）
