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使用可生物降解的聚左旋丙交酯-乙交酯(PLGA)髓内植入物治疗小儿前臂骨干骨折:一项纵向研究。

Pediatric Diaphyseal Forearm Fracture Management with Biodegradable Poly-L-Lactide-Co-Glycolide (PLGA) Intramedullary Implants: A Longitudinal Study.

作者信息

Lőrincz Aba, Lengyel Ágnes Mária, Kedves András, Nudelman Hermann, Józsa Gergő

机构信息

Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, 7624 Pécs, Hungary.

Institute of Information and Electrical Technology, Faculty of Engineering and Information Technology, University of Pécs, Boszorkány Street 2, 7624 Pécs, Hungary.

出版信息

J Clin Med. 2024 Jul 10;13(14):4036. doi: 10.3390/jcm13144036.

Abstract

Pediatric forearm fractures represent a substantial proportion of childhood injuries, requiring effective and minimally invasive treatments. Our study investigated the mid-term outcomes of biodegradable poly-L-lactide-co-glycolide (PLGA) intramedullary implants in managing diaphyseal forearm fractures in children. A follow-up cohort study was conducted with 38 patients treated with PLGA implants. Control examinations were performed one year post-operation, assessing bone healing through radiographic evaluations and functional outcomes using injured and uninjured limb range of motion (ROM) comparisons. Scarring was evaluated employing the Vancouver Scar Scale (VSS), and satisfaction via a questionnaire. Children were predominantly female (76.4%), with a mean age of 9.71 (SD: 2.69) years. Effective fracture stabilization and bone healing were found in all patients, with a minor reduction (mean difference of -1.5°, = 0.282) in elbow flexion on the operated side (139.3°) compared to the intact (140.8°). Elbow extension presented negligible average changes (0.2°, = 0.098). Forearm movements were slightly reduced on the operated side (mean pronation: 80.8° vs. 83.7°, = 0.166; average supination: 83.5° vs. 85.7°, = 0.141). Wrist palmar flexion and dorsiflexion showed no significant differences. VSS ratings indicated minimal scarring (mean guardian and doctor scores were 1.13 and 0.55, respectively, = 0.020), and all patients reported satisfaction with the treatment outcomes. Biodegradable implants are effective for pediatric forearm fractures, providing stable bone healing while preserving functional ROM with minimal scarring and high patient satisfaction. PLGA proved to be a viable alternative to traditional metal implants, eliminating secondary removal surgeries.

摘要

小儿前臂骨折在儿童损伤中占相当大的比例,需要有效且微创的治疗方法。我们的研究调查了可生物降解的聚-L-丙交酯-共-乙交酯(PLGA)髓内植入物治疗儿童前臂骨干骨折的中期疗效。对38例接受PLGA植入物治疗的患者进行了随访队列研究。术后一年进行对照检查,通过影像学评估评估骨愈合情况,并使用受伤和未受伤肢体的活动范围(ROM)比较来评估功能结果。采用温哥华瘢痕量表(VSS)评估瘢痕形成情况,并通过问卷调查评估满意度。儿童以女性为主(76.4%),平均年龄为9.71岁(标准差:2.69)。所有患者均实现了有效的骨折固定和骨愈合,与未受伤侧(140.8°)相比,手术侧的肘关节屈曲略有减少(平均差异为-1.5°,P = 0.282)(139.3°)。肘关节伸展的平均变化可忽略不计(0.2°,P = 0.098)。手术侧的前臂活动略有减少(平均旋前:80.8°对83.7°,P = 0.166;平均旋后:83.5°对85.7°,P = 0.141)。腕关节掌屈和背屈无显著差异。VSS评分显示瘢痕形成最小(监护人平均评分为1.13,医生平均评分为0.55,P = 0.020),所有患者均对治疗结果表示满意。可生物降解植入物对小儿前臂骨折有效,能提供稳定的骨愈合,同时保留功能ROM,瘢痕形成最小,患者满意度高。事实证明,PLGA是传统金属植入物的可行替代品,无需二次取出手术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dcf/11277197/3dd77b313e48/jcm-13-04036-g001.jpg

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