Department of Sports Medicine, Medical Faculty, Van Yüzüncü Yıl University, Van 65090, Turkey.
Department of Infectious Diseases and Clinical Microbiology, Medical Faculty, Van Yüzüncü Yıl University, Van 65090, Turkey.
Medicina (Kaunas). 2024 Jul 14;60(7):1131. doi: 10.3390/medicina60071131.
: Differentiation between brucella spondylodiscitis and Modic type I changes (MC1) includes difficulties. Hematological inflammatory indices (HII) such as neutrophil to lymphocyte ratio (NLR) and aggregate index of systemic inflammation (AISI) are suggested as indicators of inflammation and infection and have diagnostic, prognostic, and predictive roles in various diseases. This study aimed to evaluate differences between brucella spondylodiscitis and MC1 in terms of HII. : Thirty-five patients with brucella spondylodiscitis and thirty-seven with MC1 were enrolled in the study. Brucella spondylodiscitis and MC1 were diagnosed by microbiological, serological, and radiological diagnostic tools. HII (NLR, MLR, PLR, NLPR, SII, SIRI, AISI) were derived from baseline complete blood count. : The two groups were similar for age ( = 0.579) and gender ( = 0.092), leukocyte ( = 0.127), neutrophil ( = 0.366), lymphocyte ( = 0.090), and monocyte ( = 0.756) scores. The Brucella spondylodiscitis group had significantly lower pain duration ( < 0.001), higher CRP and ESR levels ( < 0.001), and lower platelet count ( = 0.047) than the MC1 group. The two groups had similarity in terms of HII: NLR ( = 0.553), MLR ( = 0.294), PLR ( = 0.772), NLPR ( = 0.115), SII ( = 0.798), SIRI ( = 0.447), and AISI ( = 0.248). : Increased HII can be used to differentiate infectious and non-infectious conditions, but this may be invalid in brucellosis. However, pain duration, CRP and ESR levels, and platelet count may be useful to distinguish brucella spondylodiscitis from MC1.
布鲁氏菌性脊椎炎和 Modic 型 I 改变（MC1）的鉴别存在困难。中性粒细胞与淋巴细胞比值（NLR）和全身炎症综合指数（AISI）等血液炎症指数（HII）被认为是炎症和感染的指标，在各种疾病中有诊断、预后和预测作用。本研究旨在评估 HII 在布鲁氏菌性脊椎炎和 MC1 之间的差异。
研究纳入了 35 例布鲁氏菌性脊椎炎患者和 37 例 MC1 患者。通过微生物学、血清学和影像学诊断工具诊断布鲁氏菌性脊椎炎和 MC1。从基线全血细胞计数中得出 HII（NLR、MLR、PLR、NLPR、SII、SIRI、AISI）。
两组在年龄（=0.579）和性别（=0.092）、白细胞（=0.127）、中性粒细胞（=0.366）、淋巴细胞（=0.090）和单核细胞（=0.756）评分方面相似。布鲁氏菌性脊椎炎组的疼痛持续时间明显较短（<0.001），CRP 和 ESR 水平较高（<0.001），血小板计数较低（=0.047）。两组 HII 相似：NLR（=0.553）、MLR（=0.294）、PLR（=0.772）、NLPR（=0.115）、SII（=0.798）、SIRI（=0.447）和 AISI（=0.248）。
HII 升高可用于鉴别感染性和非感染性疾病，但在布鲁氏菌病中可能无效。然而，疼痛持续时间、CRP 和 ESR 水平以及血小板计数可能有助于区分布鲁氏菌性脊椎炎和 MC1。
