Baran Ali Irfan, Binici Irfan, Arslan Yusuf, Hakseven Karaduman Zekiye, Ilter Server, Tarcan Tayyar, Unal Murat
Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Van Yuzuncu Yıl University, Van 65080, Turkey.
Department of Infectious Diseases and Clinical Microbiology, Batman Training and Research Hospital, Batman 72000, Turkey.
Biomedicines. 2024 Sep 10;12(9):2059. doi: 10.3390/biomedicines12092059.
Infectious spondylodiscitis is a life-threatening disease and has some challenges in terms of diagnostic, differentiative, and therapeutic processes. Therefore, rapid and effective management of infectious spondylodiscitis is necessary. Hematological inflammation indices (HIIs) such as the neutrophil/lymphocyte ratio and aggregate index of systemic inflammation are derived from blood cells and used as diagnostic, prognostic, predictive, and treatment monitoring indicators. This study aimed to evaluate HIIs for discriminating between infectious spondylodiscitis pathogens. This retrospective comparative study included 116 patients with infectious spondylodiscitis. According to the responsible infectious pathogens, three types of infectious spondylodiscitis were defined: (n = 51), pyogenic (n = 43), and tuberculous (n = 22). The HIIs were derived from baseline complete blood counts. The three types of infectious spondylodiscitis were statistically compared for the HII scores. We found that the group had significantly lower HII scores than the pyogenic group ( < 0.05). Also, the group had significantly lower HII scores than the tuberculous group ( < 0.05). However, no significant differences were found between the pyogenic and tuberculous groups regarding HIIs ( > 0.05). In conclusion, the HIIs may be considered in the differentiation between spondylodiscitis and other types of infectious spondylodiscitis.
感染性脊椎椎间盘炎是一种危及生命的疾病，在诊断、鉴别诊断和治疗过程中存在一些挑战。因此，对感染性脊椎椎间盘炎进行快速有效的管理是必要的。血液学炎症指标（HIIs），如中性粒细胞/淋巴细胞比值和全身炎症聚集指数，源自血细胞，并用作诊断、预后、预测和治疗监测指标。本研究旨在评估HIIs在鉴别感染性脊椎椎间盘炎病原体方面的作用。这项回顾性比较研究纳入了116例感染性脊椎椎间盘炎患者。根据致病病原体，将感染性脊椎椎间盘炎分为三种类型：（n = 51），化脓性（n = 43）和结核性（n = 22）。HIIs源自基线全血细胞计数。对三种类型的感染性脊椎椎间盘炎的HII评分进行统计学比较。我们发现，该组的HII评分显著低于化脓性组（<0.05）。此外，该组的HII评分显著低于结核性组（<0.05）。然而，化脓性组和结核性组之间在HIIs方面未发现显著差异（>0.05）。总之，在鉴别脊椎椎间盘炎和其他类型的感染性脊椎椎间盘炎时可考虑HIIs。
