Służały Piotr, Paśko Paweł, Galanty Agnieszka
Department of Pharmacognosy, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.
Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, Medyczna 9, 30-688 Cracow, Poland.
Plants (Basel). 2024 Jul 20;13(14):1985. doi: 10.3390/plants13141985.
The hepatoprotective effects of natural products have been a significant focus in recent decades due to the growing demand for the help in the treatment of hepatic impairments. This review specifically delves into the findings of clinical trials involving 13 selected natural products, namely plants and their derived compounds (e.g., artichoke, berberine, and turmeric), algae (e.g., spirulina), probiotics, and other products like phospholipids and vitamin D. A literature search was performed in the Scopus database, PubMed, and Google Scholar, covering all articles found up to June 2024. Artichoke, berberine, chlorella, chicory, green tea, probiotics, phospholipids, schisandra, silymarin, spirulina, and vitamin D caused a decrease in liver enzymes, while for cinnamon and turmeric such an effect was either not observed or not convincing. The presented results indicate that some natural products might satisfactorily improve hepatic outcomes in NAFLD, NASH, and other liver disorders; however, further studies and metanalyses are needed to clearly demonstrate their effectiveness.
由于治疗肝脏损伤的需求不断增加，天然产物的肝脏保护作用在近几十年来一直是一个重要的研究重点。本综述特别深入探讨了涉及13种选定天然产物的临床试验结果，这些天然产物包括植物及其衍生化合物（如洋蓟、黄连素和姜黄）、藻类（如螺旋藻）、益生菌以及其他产品，如磷脂和维生素D。在Scopus数据库、PubMed和谷歌学术上进行了文献检索，涵盖了截至2024年6月找到的所有文章。洋蓟、黄连素、小球藻、菊苣、绿茶、益生菌、磷脂、五味子、水飞蓟素、螺旋藻和维生素D可使肝酶降低，而肉桂和姜黄则未观察到这种效果或效果不明显。所呈现的结果表明，一些天然产物可能会令人满意地改善非酒精性脂肪性肝病、非酒精性脂肪性肝炎和其他肝脏疾病的肝脏预后；然而，需要进一步的研究和荟萃分析来明确证明它们的有效性。
