鼠李糖乳杆菌 GG 疗法对中重度酒精性肝炎患者肝脏和饮酒评估的有益影响。
The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis.
机构信息
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, USA.
Robley Rex VA Medical Center, Louisville, Kentucky, USA.
出版信息
Am J Gastroenterol. 2023 Aug 1;118(8):1457-1460. doi: 10.14309/ajg.0000000000002283. Epub 2023 Apr 11.
Abstract
INTRODUCTION
We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking in patients with alcohol use disorder and moderately severe alcohol-associated hepatitis.
METHODS
Forty-six male and female individuals with alcohol use disorder and moderate alcohol-associated hepatitis (12 ≤ model for end-stage liver disease score < 20, aged 21-67 years) received either LGG (n = 24) or placebo (n = 22). Data were collected/assessed at baseline and at 1, 3, and 6 months.
RESULTS
LGG treatment was associated with a significant reduction in liver injury after 1 month. Six months of LGG treatment reduced heavy drinking levels to social or abstinence levels.
DISCUSSION
LGG treatment was associated with an improvement in both liver injury and drinking.
摘要
简介
我们研究了每日口服鼠李糖乳杆菌 GG（LGG）对减少酒精使用障碍和伴有中度酒精性肝炎患者的肝损伤/严重程度和饮酒的影响。
方法
46 名男性和女性酒精使用障碍且伴有中度酒精性肝炎患者（12≤终末期肝病模型评分<20，年龄 21-67 岁）分别接受 LGG（n=24）或安慰剂（n=22）治疗。数据在基线和 1、3 和 6 个月时收集/评估。
结果
LGG 治疗 1 个月后肝损伤显著降低。6 个月的 LGG 治疗将重度饮酒水平降低至社交或戒酒水平。
讨论
LGG 治疗与肝损伤和饮酒的改善有关。
相似文献
1
The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis.鼠李糖乳杆菌 GG 疗法对中重度酒精性肝炎患者肝脏和饮酒评估的有益影响。
Am J Gastroenterol. 2023 Aug 1;118(8):1457-1460. doi: 10.14309/ajg.0000000000002283. Epub 2023 Apr 11.
2
Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis.在酒精性脂肪性肝炎大鼠模型中，鼠李糖乳杆菌GG治疗可改善酒精诱导的肠道氧化应激、肠道通透性增加及肝损伤。
Alcohol. 2009 Mar;43(2):163-72. doi: 10.1016/j.alcohol.2008.12.009.
3
Granules Dose-Dependently Balance Intestinal Microbiome Disorders and Ameliorate Chronic Alcohol-Induced Liver Injury.颗粒剂剂量依赖性地平衡肠道微生物失调并改善慢性酒精性肝损伤。
J Med Food. 2020 Feb;23(2):114-124. doi: 10.1089/jmf.2018.4357. Epub 2019 Nov 20.
4
Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury.罗伊氏乳杆菌 GG 减少慢性酒精性肝损伤中肝脏 TNFα 的产生和炎症。
J Nutr Biochem. 2013 Sep;24(9):1609-15. doi: 10.1016/j.jnutbio.2013.02.001. Epub 2013 Apr 22.
5
Lactobacillus rhamnosus GG supernatant promotes intestinal barrier function, balances Treg and TH17 cells and ameliorates hepatic injury in a mouse model of chronic-binge alcohol feeding.鼠李糖乳杆菌GG上清液可促进肠道屏障功能，平衡调节性T细胞和辅助性T细胞17，并改善慢性暴饮酒精喂养小鼠模型中的肝损伤。
Toxicol Lett. 2016 Jan 22;241:103-10. doi: 10.1016/j.toxlet.2015.11.019. Epub 2015 Nov 23.
6
Intake of GG (LGG) fermented milk before drinking alcohol reduces acetaldehyde levels and duration of flushing in drinkers with wild-type and heterozygous mutant : a randomized, blinded crossover controlled trial.饮酒前摄入鼠李糖乳杆菌发酵乳可降低野生型和杂合突变型饮酒者的乙醛水平及脸红持续时间：一项随机、双盲交叉对照试验
Food Funct. 2021 Oct 19;12(20):10147-10159. doi: 10.1039/d1fo01485d.
7
Lactobacillus rhamnosus GG combined with inosine ameliorates alcohol-induced liver injury through regulation of intestinal barrier and Treg/Th1 cells.鼠李糖乳杆菌GG联合肌苷通过调节肠道屏障和Treg/Th1细胞改善酒精性肝损伤。
Toxicol Appl Pharmacol. 2022 Mar 15;439:115923. doi: 10.1016/j.taap.2022.115923. Epub 2022 Feb 15.
8
Ehealth: low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome.电子健康：低发酵性寡糖、双糖、单糖和多元醇饮食与鼠李糖乳杆菌GG治疗肠易激综合征的比较
World J Gastroenterol. 2014 Nov 21;20(43):16215-26. doi: 10.3748/wjg.v20.i43.16215.
9
Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury.鼠李糖乳杆菌 GG 治疗增强肠道缺氧诱导因子，促进肠道完整性，改善酒精性肝损伤。
Am J Pathol. 2011 Dec;179(6):2866-75. doi: 10.1016/j.ajpath.2011.08.039.
10
Lactobacillus rhamnosus GG protects against non-alcoholic fatty liver disease in mice.鼠李糖乳杆菌 GG 可预防非酒精性脂肪性肝病。
PLoS One. 2014 Jan 27;9(1):e80169. doi: 10.1371/journal.pone.0080169. eCollection 2014.
引用本文的文献
1
Targeting gut health: Probiotics as promising therapeutics in alcohol-related liver disease management.针对肠道健康：益生菌作为酒精性肝病管理中有前景的治疗方法。
AIMS Microbiol. 2025 Jun 11;11(2):410-435. doi: 10.3934/microbiol.2025019. eCollection 2025.
2
Exploration and Validation of Key Genes and Immune Infiltration in Alcoholic Hepatitis.酒精性肝炎关键基因及免疫浸润的探索与验证
J Inflamm Res. 2025 Jun 24;18:8243-8262. doi: 10.2147/JIR.S514515. eCollection 2025.
3
Compositional and Metabolomic Shifts of the Gut Microbiome in Alcohol-Related Liver Disease.酒精性肝病中肠道微生物群的组成和代谢组学变化
J Gastroenterol Hepatol. 2025 Jun 24. doi: 10.1111/jgh.17038.
4
Interaction Between Microbiota and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and New Therapeutic Opportunities.微生物群与免疫的相互作用：分子机制、生物学功能、疾病及新的治疗机遇
MedComm (2020). 2025 Jun 19;6(7):e70265. doi: 10.1002/mco2.70265. eCollection 2025 Jul.
5
Gut microbiota in liver diseases: initiation, development and therapy.肝脏疾病中的肠道微生物群：起始、发展与治疗
Front Med (Lausanne). 2025 Jun 4;12:1615839. doi: 10.3389/fmed.2025.1615839. eCollection 2025.
6
Food plants as adjuvant medicines: a review of protective effects and clinical potential in alcoholic liver disease.作为辅助药物的食用植物：对酒精性肝病保护作用及临床潜力的综述
Front Pharmacol. 2025 May 22;16:1586238. doi: 10.3389/fphar.2025.1586238. eCollection 2025.
7
Role of Intestinal Microbiome in Potentiating Inflammation and Predicting Outcomes in Alcohol-Associated Cirrhosis.肠道微生物群在增强酒精性肝硬化炎症及预测预后中的作用
Gastroenterol Clin North Am. 2025 Jun;54(2):453-467. doi: 10.1016/j.gtc.2024.12.001. Epub 2025 Jan 18.
8
ACG Clinical Guideline: Malnutrition and Nutritional Recommendations in Liver Disease.美国胃肠病学会临床指南：肝病中的营养不良与营养建议
Am J Gastroenterol. 2025 May 1;120(5):950-972. doi: 10.14309/ajg.0000000000003379. Epub 2025 May 2.
9
Treatment of alcohol use disorder in alcohol-associated liver disease: A meta-analysis.酒精相关性肝病中酒精使用障碍的治疗：一项荟萃分析。
Hepatol Commun. 2025 Apr 30;9(5). doi: 10.1097/HC9.0000000000000686. eCollection 2025 May 1.
10
Recent advances in therapeutic probiotics: insights from human trials.治疗性益生菌的最新进展：来自人体试验的见解
Clin Microbiol Rev. 2025 Jun 12;38(2):e0024024. doi: 10.1128/cmr.00240-24. Epub 2025 Apr 22.
本文引用的文献
1
Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice.酒精使用障碍患者粪便移植后酒精偏好和摄入量降低可传播至无菌小鼠。
Nat Commun. 2022 Oct 19;13(1):6198. doi: 10.1038/s41467-022-34054-6.
2
IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis.白细胞介素-1 受体拮抗剂联合己酮可可碱和锌治疗严重酒精相关性肝炎。
Hepatology. 2022 Oct;76(4):1058-1068. doi: 10.1002/hep.32478. Epub 2022 Jun 2.
3
A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder.一项关于酒精使用障碍粪便微生物群移植的随机临床试验。
Hepatology. 2021 May;73(5):1688-1700. doi: 10.1002/hep.31496. Epub 2021 Mar 16.
4
Probiotic Lactobacillus rhamnosus GG Prevents Liver Fibrosis Through Inhibiting Hepatic Bile Acid Synthesis and Enhancing Bile Acid Excretion in Mice.鼠李糖乳杆菌 GG 通过抑制肝脏胆汁酸合成和增强胆汁酸排泄预防肝纤维化。
Hepatology. 2020 Jun;71(6):2050-2066. doi: 10.1002/hep.30975. Epub 2020 Mar 16.
5
Diagnosis and Treatment of Alcohol-Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases.酒精性肝病的诊断与治疗：美国肝病研究协会2019年实践指南
Hepatology. 2020 Jan;71(1):306-333. doi: 10.1002/hep.30866.
6
Alcohol-related liver disease: Areas of consensus, unmet needs and opportunities for further study.酒精性肝病：共识领域、未满足需求和进一步研究的机会。
J Hepatol. 2019 Mar;70(3):521-530. doi: 10.1016/j.jhep.2018.10.041. Epub 2019 Jan 15.
7
Liver Injury and Endotoxemia in Male and Female Alcohol-Dependent Individuals Admitted to an Alcohol Treatment Program.入住酒精治疗项目的男性和女性酒精依赖个体的肝损伤和内毒素血症
Alcohol Clin Exp Res. 2017 Apr;41(4):747-757. doi: 10.1111/acer.13346. Epub 2017 Mar 2.
8
Mental health: thinking from the gut.心理健康：从肠道说起
Nature. 2015 Feb 26;518(7540):S12-5. doi: 10.1038/518S13a.
9
Converging actions of alcohol on liver and brain immune signaling.酒精对肝脏和大脑免疫信号的汇聚作用。
Int Rev Neurobiol. 2014;118:359-80. doi: 10.1016/B978-0-12-801284-0.00011-7.
10
Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury.鼠李糖乳杆菌 GG 培养上清液改善急性酒精诱导的肠道通透性和肝损伤。
Am J Physiol Gastrointest Liver Physiol. 2012 Jul;303(1):G32-41. doi: 10.1152/ajpgi.00024.2012. Epub 2012 Apr 26.
Zotero 插件