Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, Louisville, Kentucky, USA.
Robley Rex VA Medical Center, Louisville, Kentucky, USA.
Am J Gastroenterol. 2023 Aug 1;118(8):1457-1460. doi: 10.14309/ajg.0000000000002283. Epub 2023 Apr 11.
We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking in patients with alcohol use disorder and moderately severe alcohol-associated hepatitis.
Forty-six male and female individuals with alcohol use disorder and moderate alcohol-associated hepatitis (12 ≤ model for end-stage liver disease score < 20, aged 21-67 years) received either LGG (n = 24) or placebo (n = 22). Data were collected/assessed at baseline and at 1, 3, and 6 months.
LGG treatment was associated with a significant reduction in liver injury after 1 month. Six months of LGG treatment reduced heavy drinking levels to social or abstinence levels.
LGG treatment was associated with an improvement in both liver injury and drinking.
我们研究了每日口服鼠李糖乳杆菌 GG（LGG）对减少酒精使用障碍和伴有中度酒精性肝炎患者的肝损伤/严重程度和饮酒的影响。
46 名男性和女性酒精使用障碍且伴有中度酒精性肝炎患者（12≤终末期肝病模型评分<20，年龄 21-67 岁）分别接受 LGG（n=24）或安慰剂（n=22）治疗。数据在基线和 1、3 和 6 个月时收集/评估。
LGG 治疗 1 个月后肝损伤显著降低。6 个月的 LGG 治疗将重度饮酒水平降低至社交或戒酒水平。
LGG 治疗与肝损伤和饮酒的改善有关。
