Hypertension and Cardiovascular Risk Research Center, Medical and Surgical Sciences Department, Sant'Orsola-Malpighi University Hospital, 40138 Bologna, Italy.
IRCCS Policlinico S. Orsola-Malpighi di Bologna, 40138 Bologna, Italy.
Nutrients. 2022 May 18;14(10):2099. doi: 10.3390/nu14102099.
We aimed to evaluate if dietary supplementation with a nutraceutical compound (Eufortyn Colesterolo Plus) containing standardized bergamot polyphenolic fraction phytosome (Vazguard), artichoke extract (Pycrinil), artichoke dry extract. ( L.), Q10 phytosome(Ubiqosome) and zinc, could positively affect serum lipids concentration, systemic inflammation and indexes of non-alcoholic fatty liver disease (NAFLD) in 60 healthy subjects with polygenic hypercholesterolemia. Participants were adhering to a low-fat, low-sodium Mediterranean diet for a month before being randomly allocated to 8-week treatment with 1 pill each day of either Eufortyn Colesterolo Plus or placebo. Dietary supplementation with Eufortyn Colesterolo Plus was associated with significant improvement in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), high-sensitivity C-reactive protein (hs-CRP) and endothelial reactivity (ER) in comparison with baseline, and with significant reductions in waist circumference, TC, LDL-C, LDL-C/HDL-C, lipid accumulation product and fatty liver index compared to placebo. The study shows that dietary supplementation with standardized bergamot polyphenolic fraction phytosome, artichoke extracts, Q10 phytosome and zinc safely exerts significant improvements in serum lipids, systemic inflammation, indexes of NAFLD and endothelial reactivity in healthy subjects with moderate hypercholesterolemia.
我们旨在评估在含有标准化佛手多酚类植物提取物（Vazguard）、朝鲜蓟提取物（Pycrinil）、朝鲜蓟干提取物（L.）、Q10 植物提取物（Ubiqosome）和锌的营养补充剂（Eufortyn Colesterolo Plus）的饮食补充是否能积极影响血清脂质浓度、全身炎症和非酒精性脂肪性肝病（NAFLD）指数在 60 名患有多基因高胆固醇血症的健康受试者中。参与者在接受低脂肪、低钠的地中海饮食一个月后，随机分配到 8 周的治疗组，每天服用 1 片 Eufortyn Colesterolo Plus 或安慰剂。与基线相比，Eufortyn Colesterolo Plus 的饮食补充与总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、非高密度脂蛋白胆固醇（非-HDL-C）、高敏 C 反应蛋白（hs-CRP）和内皮反应性（ER）的显著改善相关，与安慰剂相比，腰围、TC、LDL-C、LDL-C/HDL-C、脂质蓄积产物和脂肪肝指数也显著降低。研究表明，标准化佛手多酚类植物提取物、朝鲜蓟提取物、Q10 植物提取物和锌的饮食补充安全地在中度高胆固醇血症的健康受试者中显著改善血清脂质、全身炎症、NAFLD 指数和内皮反应性。
