Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, 13123 East 16th Avenue, B-395, Aurora, CO 80045, USA.
Department of Pediatrics, Vanderbilt University Medical Center and Monroe Carell Jr. Children's Hospital at Vanderbilt, 2200 Children's Way, Doctors' Office Tower, Suite 11215, Nashville, TN 37232, USA.
Clin Chest Med. 2024 Sep;45(3):587-597. doi: 10.1016/j.ccm.2024.02.026. Epub 2024 Mar 28.
Numerous studies have examined the role of the microbiome and microbiome-based therapeutics in many childhood airway and lung diseases. In this narrative review, the authors first give a brief overview of the current methods used in microbiome research. The authors then review the literature linking the microbiome with (1) early-life acute respiratory infections due to respiratory syncytial virus, (2) childhood asthma onset, (3) cystic fibrosis, and (4) bronchopulmonary dysplasia, focusing on recent studies that have used culture-independent methods to characterize the respiratory or gut microbiome in the pediatric population.
许多研究已经探讨了微生物组及其基于微生物组的治疗方法在多种儿童气道和肺部疾病中的作用。在这篇叙述性综述中，作者首先简要概述了目前用于微生物组研究的方法。然后，作者回顾了将微生物组与（1）呼吸道合胞病毒引起的儿童期急性呼吸道感染、（2）儿童哮喘发病、（3）囊性纤维化和（4）支气管肺发育不良相关联的文献，重点关注了最近使用非培养方法来描述儿科人群呼吸或肠道微生物组的研究。
