Permall Dhivya Lakshmi, Pasha Asfia Banu, Chen Xiao-Qing, Lu Hong-Yan
Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, No 300, Guangzhou Road, Nanjing, Jiangsu Province.
Department of Pediatrics, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Turk J Pediatr. 2019;61(6):821-830. doi: 10.24953/turkjped.2019.06.001.
Permall DL, Pasha AB, Chen XQ, Lu HY. The lung microbiome in neonates. Turk J Pediatr 2019; 61: 821-830. Despite the advent of culture-independent techniques to identify members of the microbiome, studies focusing on the lung microbiome of neonates are scarce. Understanding the role of the microbiome in the pathogenesis of pulmonary conditions affecting newborns could lead to the initiation of pioneering therapeutic interventions, which could potentially prevent lifelong disability. Bronchopulmonary dysplasia (BPD) has been associated with a less diverse microbiome, presence of Ureaplasma species and reduced Lactobacillus detection. Additionally, the potential role of microbial dysbiosis in the pathogenesis of asthma, cystic fibrosis and pneumonia has been described. There has also been a surge of interest in attempting to elucidate the interactions between the airway and gut microbiomes and their bearings on respiratory health and diseases to eventually broaden the scope of therapeutic interventions.
佩马尔·DL、帕夏·AB、陈XQ、卢HY。新生儿肺部微生物群。《土耳其儿科学杂志》2019年；61: 821 - 830。尽管出现了不依赖培养的技术来鉴定微生物群成员，但关注新生儿肺部微生物群的研究仍然很少。了解微生物群在影响新生儿的肺部疾病发病机制中的作用，可能会引发开创性的治疗干预措施，这有可能预防终身残疾。支气管肺发育不良（BPD）与微生物群多样性较低、脲原体属的存在以及乳酸杆菌检测减少有关。此外，微生物群落失调在哮喘、囊性纤维化和肺炎发病机制中的潜在作用也已被描述。人们也越来越有兴趣试图阐明气道和肠道微生物群之间的相互作用及其对呼吸健康和疾病的影响，以最终扩大治疗干预的范围。
