Division of Pulmonary & Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Expert Rev Respir Med. 2013 Jun;7(3):245-57. doi: 10.1586/ers.13.24.
Novel culture-independent techniques have recently demonstrated that the lower respiratory tract, historically considered sterile in health, contains diverse communities of microbes: the lung microbiome. Increasing evidence supports the concept that a distinct microbiota of the lower respiratory tract is present both in health and in various respiratory diseases, although the biological and clinical significance of these findings remains undetermined. In this article, the authors review and synthesize published reports of the lung microbiota of healthy and diseased subjects, discuss trends of microbial diversity and constitution across disease states, and look to the extrapulmonary microbiome for hypotheses and future directions for study.
最近，一些新颖的非培养技术研究表明，历史上被认为在健康状态下无菌的下呼吸道，其实含有多种多样的微生物群落：肺部微生物组。越来越多的证据支持这样一种概念，即健康人群和各种呼吸道疾病患者的下呼吸道都存在独特的微生物群，但这些发现的生物学和临床意义尚不确定。在本文中，作者对健康和患病受试者的肺部微生物组的已发表报告进行了综述和综合分析，讨论了疾病状态下微生物多样性和组成的趋势，并参考了肺外微生物组，提出了一些假说和未来的研究方向。
