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porcelain 主动脉和四重颅外血管闭塞:一例尽管血管严重阻塞但神经缺损极小的病例。

Porcelain Aorta and Quadruple Extracranial Vessel Occlusion: A Case of Minimal Neurological Deficits Despite Severe Vascular Blockages.

机构信息

Shiraz University of Medical Sciences, Shiraz, Iran.

Professor Kojuri Cardiology Clinic, Niayesh Medical Complex, Shiraz, Iran.

出版信息

Am J Case Rep. 2024 Jul 29;25:e944099. doi: 10.12659/AJCR.944099.

Abstract

BACKGROUND Cerebrovascular occlusion is a critical health concern associated with strokes, a leading cause of mortality worldwide. Large vessel occlusion, constituting a significant portion of acute ischemic strokes, presents serious patient outcomes. Occlusions involving multiple extracranial vessels are rare but pose challenges in early detection due to potential absence of overt symptoms. CASE REPORT A 65-year-old man with a significant smoking history and no prior history of hypertension or cardiovascular disease presented with recurrent generalized tonic seizures occurring 4 to 5 times daily. Despite normal neurological examinations, neck sonography indicated potential obstruction in the carotid and vertebral arteries. Conventional angiography revealed mild coronary artery plaques but complete occlusion of all cranial branches originating from the aorta, alongside porcelain aorta. Neck CT angiography confirmed complete occlusion of the supra-aortic branches of the aorta and absence of the right internal carotid artery, with evidence of proximal occlusion of the left internal carotid artery. Medical management without surgical intervention was pursued due to the patient's stable condition. He was discharged with a medication regimen including antiplatelet therapy and statins. Four-month follow-up showed significant symptom improvement, with minimal changes in brain blood flow circulation noted on CT. CONCLUSIONS This case underscores the brain's remarkable adaptive capacity in withstanding severe vascular challenges. The rarity of multiple extracranial vessel occlusions and presence of porcelain aorta further complicated the case. Utilizing advanced imaging techniques and personalized treatment approaches are crucial in managing complex vascular conditions. Ongoing research and careful monitoring are essential to advance understanding and management in such cases.

摘要

背景

脑血管阻塞是与中风相关的一个严重健康问题,是全球范围内导致死亡的主要原因。大血管阻塞是急性缺血性中风的主要部分,会导致严重的患者预后不良。涉及多个颅外血管的阻塞虽然罕见,但由于潜在的无明显症状,在早期检测时具有挑战性。

病例报告

一位 65 岁男性,有大量吸烟史,无高血压或心血管疾病史,反复出现全身性强直阵挛性癫痫发作,每天发作 4 到 5 次。尽管神经系统检查正常,但颈部超声检查提示颈动脉和椎动脉可能存在阻塞。常规血管造影显示轻度冠状动脉斑块,但所有源自主动脉的颅外分支完全阻塞,同时伴有主动脉粥样硬化。颈部 CT 血管造影证实主动脉上腔分支完全阻塞,右侧颈内动脉缺失,左侧颈内动脉近端阻塞。由于患者病情稳定,未进行手术干预,仅采取了药物治疗。他出院时的药物治疗方案包括抗血小板治疗和他汀类药物。4 个月的随访显示症状显著改善,CT 显示脑血流循环仅有微小变化。

结论

该病例强调了大脑在应对严重血管挑战时具有显著的适应能力。多个颅外血管阻塞的罕见性和主动脉粥样硬化的存在进一步使该病例复杂化。利用先进的成像技术和个性化的治疗方法对于管理复杂的血管状况至关重要。持续的研究和仔细的监测对于推进此类病例的理解和管理非常重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/281b/11299871/ee5ece2c61ed/amjcaserep-25-e944099-g001.jpg

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