Klepikov P V, Kutyrina I M, Lukovnikova L P
Ter Arkh. 1985;57(6):81-3.
A study was made of the effects of ultra-high doses of prednisolone on arterial blood pressure, electrolyte metabolism and renin-aldosterone system in 18 patients with chronic glomerulonephritis and lupus nephritis, with normal renal function and renal failure. Administration of 1,000 mg prednisolone produced a noticeable but a short-term elevation of the arterial blood pressure. After administration of 1,000 mg prednisolone the patients without renal failure noted marked increase of diuresis and natriuresis accompanied by activation of the renin-aldosterone system. In patients with renal failure, diuresis also increased, however sodium excretion with urine dramatically reduced which was accompanied by inhibition of plasma renin activity. Marked retention of sodium during institution of pulse-therapy in patients with renal failure may cause some grave complications including brain edema.
对18例慢性肾小球肾炎和狼疮性肾炎患者（包括肾功能正常和肾功能衰竭患者）进行了一项研究，观察超大剂量泼尼松龙对动脉血压、电解质代谢和肾素-醛固酮系统的影响。给予1000mg泼尼松龙可使动脉血压出现明显但短暂的升高。在给予1000mg泼尼松龙后，肾功能正常的患者尿量和尿钠排泄显著增加，同时肾素-醛固酮系统激活。肾功能衰竭患者的尿量也增加，但尿钠排泄显著减少，同时血浆肾素活性受到抑制。肾功能衰竭患者在冲击治疗期间明显的钠潴留可能会导致一些严重并发症，包括脑水肿。
