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淋巴细胞作为新冠病毒肺炎患者预后的预测指标:一项基于医院的研究。

Lymphocyte as a predictor of prognosis of COVID-19 patients: A hospital-based study.

作者信息

Biakhlupuii C, Vanlalpeka Johan, Lalrinpuia Benjamin, Devi Ksh G, Hrahsel Lalrinawmi

机构信息

Department of Physiology, Zoram Medical College, Falkawn, Aizawl, Mizoram, India.

Department of General Medicine, Zoram Medical College, Falkawn, Aizawl, Mizoram, India.

出版信息

J Family Med Prim Care. 2024 Jul;13(7):2609-2611. doi: 10.4103/jfmpc.jfmpc_1699_23. Epub 2024 Jun 28.

Abstract

INTRODUCTION

Lymphocytopenia has emerged as a simply obtained laboratory value that may correlate with prognosis. In this study we aim to study absolute Lymphocyte count after clinical recovery.

METHOD AND MATERIAL

Observational study was conducted in Covid dedicated Hospital in Mizoram. Absolute lymphocyte count is obtained from the differential leucocyte count of the patients. The obsolute Lymphocyte count at the time of hospital admission is compared with the Absolute Lymphocyte count at the time of hospital discharge after the patient obtained clinical recovery.

RESULT

Absolute Lymphocyte Count at the time of admission has a mean of 2004.48 and standard deviation of 1204.868. Absolute Lymphocyte Count at the time of discharge has a mean of 1943.68 and standard devaiton of 842.228. Pearsons correlation coefficientis showed that there is positive correlation between the variables (Correlation coeffiecient = .325). Also, the correlation is statistically significant ( < 0.05). Paired Sample t-test showed there is no statistical significant difference between Absolute Lymphocyte Count- at the time of admission and at the time of discharge ( > 0.05) at 95% Conficence Interval.

CONCLUSION

Our study showed that Absolute Lymphocyte count had no signicant difference at the time of hospital admission and after clinical recovery.

摘要

引言

淋巴细胞减少已成为一个简单获取的实验室指标,可能与预后相关。在本研究中,我们旨在研究临床康复后的绝对淋巴细胞计数。

方法与材料

在米佐拉姆邦的一家新冠专科医院进行了观察性研究。绝对淋巴细胞计数来自患者的白细胞分类计数。将患者入院时的绝对淋巴细胞计数与临床康复后出院时的绝对淋巴细胞计数进行比较。

结果

入院时绝对淋巴细胞计数的平均值为2004.48,标准差为1204.868。出院时绝对淋巴细胞计数的平均值为1943.68,标准差为842.228。皮尔逊相关系数表明变量之间存在正相关(相关系数 = 0.325)。此外,该相关性具有统计学意义(<0.05)。配对样本t检验表明,在95%置信区间内,入院时和出院时的绝对淋巴细胞计数之间没有统计学显著差异(>0.05)。

结论

我们的研究表明,入院时和临床康复后的绝对淋巴细胞计数没有显著差异。

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本文引用的文献

1
COVID-19: Developing from an Outbreak to A Pandemic.新型冠状病毒肺炎:从疫情爆发到全球大流行
Arch Med Res. 2020 Aug;51(6):582-584. doi: 10.1016/j.arcmed.2020.04.021. Epub 2020 May 13.
3
Immune-epidemiological parameters of the novel coronavirus - a perspective.新型冠状病毒的免疫流行病学参数——一个视角。
Expert Rev Clin Immunol. 2020 May;16(5):465-470. doi: 10.1080/1744666X.2020.1750954. Epub 2020 Apr 6.
4
Clinical Characteristics of Coronavirus Disease 2019 in China.《中国 2019 年冠状病毒病临床特征》
N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.
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Coronavirus infections and immune responses.冠状病毒感染与免疫应答。
J Med Virol. 2020 Apr;92(4):424-432. doi: 10.1002/jmv.25685. Epub 2020 Feb 7.

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