Dong Hanpeng, Gao Xiaojin, Li Haixia, Gao Jing, Zhang Leiming
Key Laboratory of Molecular Pharmacology and Drug Evaluation, School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Ministry of Education, Yantai University, Yantai, Shandong 264005, P.R. China.
School of Traditional Chinese Medicine, Binzhou Medical University, Yantai, Shandong 264003, P.R. China.
Exp Ther Med. 2024 Jul 4;28(3):350. doi: 10.3892/etm.2024.12639. eCollection 2024 Sep.
Intracerebral hemorrhage (ICH), known as non-traumatic cerebrovascular rupture and hemorrhage, often occurs in the deep basal brain segment. It is known for its high morbidity and mortality rates. Subarachnoid hemorrhage (SAH) is a clinical syndrome caused by the rupture of blood vessels at the base or surface of the brain that allows blood to flow directly into the subarachnoid space. It progresses quickly and typically manifests at younger ages compared with ICH. ICH and SAH are both devastating events in the category of hemorrhagic strokes and are attracting increasing attention from researchers. Flavonoids, being important natural molecules, have remarkable anti-inflammatory and antioxidant effects. Flavonoids have extensive biological activities in inflammation and oxidative stress (OS), and have protective effects in vascular function associated with cerebrovascular diseases. They have an impact on the onset of ICH and SAH by targeting various pathways, including the suppression of inflammation and OS. Recently, the role of flavonoid compounds in ICH and SAH has also received increasing interest. Thus, to serve as a resource for the prevention and treatment of ICH and SAH, the present review provided an overview of the research on flavonoid compounds in the prevention of brain damage after these two conditions have occurred.
脑出血（ICH），即非创伤性脑血管破裂出血，常发生于脑深部基底节段。其以高发病率和高死亡率而闻名。蛛网膜下腔出血（SAH）是一种由脑底部或表面血管破裂导致血液直接流入蛛网膜下腔引起的临床综合征。它进展迅速，与脑出血相比，通常在较年轻的年龄段出现。脑出血和蛛网膜下腔出血均为出血性卒中范畴内的严重事件，正吸引着研究人员越来越多的关注。黄酮类化合物作为重要的天然分子，具有显著的抗炎和抗氧化作用。黄酮类化合物在炎症和氧化应激（OS）方面具有广泛的生物学活性，对与脑血管疾病相关的血管功能具有保护作用。它们通过靶向多种途径，包括抑制炎症和氧化应激，对脑出血和蛛网膜下腔出血的发病产生影响。最近，黄酮类化合物在脑出血和蛛网膜下腔出血中的作用也越来越受到关注。因此，为作为预防和治疗脑出血及蛛网膜下腔出血的参考资料，本综述概述了黄酮类化合物在这两种情况发生后预防脑损伤方面的研究。
