State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, Sichuang, China; School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuang, China.
The Second Hospital of Traditional Chinese Medicine in Sichuan Province, Chengdu, 61003, Sichuang, China; School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuang, China.
Eur J Pharmacol. 2023 Aug 15;953:175695. doi: 10.1016/j.ejphar.2023.175695. Epub 2023 Mar 26.
The incidence of cerebral diseases is rapidly increasing worldwide, and they have become an important challenge for modern medicine. Most of the available chemical drugs used in the treatment of cerebral diseases are highly toxic and single-targeted. Therefore, novel drugs from natural resources have attracted much attention for their potential to manage cerebral diseases. Puerarin is a natural isoflavone isolated from the roots of Pueraria species such as P. lobata (Willd.) Ohwi, P. thomsonii, and P. mirifica. Several authors have reported the beneficial effects of puerarin in cerebral ischemic disease, intracerebral hemorrhage, vascular dementia, Alzheimer's disease, Parkinson's disease, depression, anxiety, and traumatic brain injury. This review summarizes the brain pharmacokinetics, brain drug delivery system, clinical use (in cerebral diseases), toxicity, and the adverse clinical reactions of puerarin. We have systematically presented the pharmacological actions and the molecular mechanisms of puerarin in various cerebral diseases to provide a direction for future researches on the therapeutic use of puerarin in cerebral diseases.
脑疾病的发病率在全球范围内迅速上升，已成为现代医学的重要挑战。治疗脑疾病的大多数现有化学药物具有高毒性和单靶点作用。因此，来自天然资源的新型药物因其治疗脑疾病的潜力而引起了广泛关注。葛根素是从葛根（如野葛、粉葛和泰国葛等）的根部分离得到的天然异黄酮。已有多位作者报道了葛根素对脑缺血性疾病、脑出血、血管性痴呆、阿尔茨海默病、帕金森病、抑郁、焦虑和创伤性脑损伤的有益作用。本综述总结了葛根素的脑药代动力学、脑药物传递系统、临床应用（在脑疾病中的应用）、毒性和不良反应。我们系统地阐述了葛根素在各种脑疾病中的药理作用和分子机制，为未来研究葛根素在脑疾病中的治疗用途提供了方向。
