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骨髓微环境中的衰老：治疗相关髓系肿瘤发生发展的驱动因素。

Senescence in the bone marrow microenvironment: A driver in development of therapy-related myeloid neoplasms.

作者信息

Guilatco Angelo Jose, Shah Mithun Vinod, Weivoda Megan Moore

机构信息

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Cancer Biology Program, University of Michigan, Ann Arbor, MI, USA.

出版信息

J Bone Oncol. 2024 Jul 5;47:100620. doi: 10.1016/j.jbo.2024.100620. eCollection 2024 Aug.

DOI:10.1016/j.jbo.2024.100620
PMID:39072049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11280103/
Abstract

Therapy-related myeloid neoplasms (t-MN) are a growing concern due to the continued use of cytotoxic therapies to treat malignancies. Cytotoxic therapies have been shown to drive therapy-induced senescence in normal tissues, including in the bone marrow microenvironment (BMME), which plays a crucial role in supporting normal hematopoiesis. This review examines recent work that focuses on the contribution of BMME senescence to t-MN pathogenesis, as well as offers a perspective on potential opportunities for therapeutic intervention.

摘要

由于持续使用细胞毒性疗法治疗恶性肿瘤，与治疗相关的髓系肿瘤（t-MN）日益受到关注。细胞毒性疗法已被证明会在正常组织中引发治疗诱导的衰老，包括在骨髓微环境（BMME）中，而骨髓微环境在支持正常造血过程中起着关键作用。本综述探讨了近期聚焦于骨髓微环境衰老对t-MN发病机制贡献的研究工作，并对治疗干预的潜在机会提出了观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c2/11280103/7e2c237c6154/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c2/11280103/7e2c237c6154/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c2/11280103/7e2c237c6154/gr1.jpg

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The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency.细胞衰老在环磷酰胺诱导的原发性卵巢功能不全中的作用。
Int J Mol Sci. 2023 Dec 6;24(24):17193. doi: 10.3390/ijms242417193.
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Elimination of Senescent Osteocytes by Bone-Targeting Delivery of β-Galactose-Modified Maytansinoid Prevents Age-Related Bone Loss.
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Adv Healthc Mater. 2024 Mar;13(8):e2302972. doi: 10.1002/adhm.202302972. Epub 2023 Dec 15.
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RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment.RAB27B 调控的外泌体通过抵抗衰老和与微环境的串扰来介导 LSC 的维持。
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J Vis Exp. 2023 Nov 10(201). doi: 10.3791/66093.
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