The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Traditional Chinese Medicine, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, China.
Front Immunol. 2024 Jul 12;15:1387582. doi: 10.3389/fimmu.2024.1387582. eCollection 2024.
N-methyladenosine (mA) is a chemical modification of RNA and has become a widely discussed topic among scientific researchers in recent years. It is distributed in various organisms, including eukaryotes and bacteria. It has been found that mA is composed of writers, erasers and readers and is involved in biological functions such as splicing, transport and translation of RNA. The balance of the human immune microenvironment is important for human health abnormalities. Increasing studies have found that mA affects the development of immune diseases such as inflammatory enteritis and systemic lupus erythematosus (SLE) by participating in the homeostatic regulation of the immune microenvironment . In this manuscript, we introduce the composition, biological function, regulation of mA in the immune microenvironment and its progression in various immune diseases, providing new targets and directions for the treatment of immune diseases in clinical practice.
N6-甲基腺苷（m6A）是 RNA 的一种化学修饰，近年来已成为科学研究人员广泛讨论的话题。它分布于各种生物中，包括真核生物和细菌。研究发现，m6A 由 writers、erasers 和 readers 组成，参与 RNA 的剪接、运输和翻译等生物学功能。人类免疫微环境的平衡对于人类健康异常至关重要。越来越多的研究发现，m6A 通过参与免疫微环境的稳态调节，影响炎症性肠炎和系统性红斑狼疮（SLE）等免疫性疾病的发展。在本手稿中，我们介绍了 m6A 在免疫微环境中的组成、生物学功能、调节及其在各种免疫性疾病中的进展，为临床实践中免疫性疾病的治疗提供了新的靶点和方向。
