Nordøy A
Acta Med Scand Suppl. 1985;701:15-22. doi: 10.1111/j.0954-6820.1985.tb08886.x.
The dietary fatty acids include saturated and unsaturated fatty acids of the n-9, n-6 and n-3 families. Their quantity and quality are reflected in the plasma lipoproteins. The platelet and endothelial cell lipid composition also is influenced by the dietary fatty acids. These changes have consequences for cellular lipid and prostanoid metabolism and other cellular functions which could be related to the thrombosis mechanism. A high intake of saturated and n-9 unsaturated fatty acids induces changes in plasma, platelets and endothelial cells favouring thrombosis and atherosclerosis. By contrast, both n-6 and n-3 fatty acids give rise to plasma lipoprotein and cellular lipid composition that counteract atherosclerosis and thrombosis. The ideal balance between the various dietary fatty acids is not known. Experimental and epidemiological studies support the recommendation of a low saturated fat intake with supplement of both n-6 and -3 polyunsaturated fatty acids.
膳食脂肪酸包括n-9、n-6和n-3族的饱和脂肪酸和不饱和脂肪酸。它们的数量和质量反映在血浆脂蛋白中。血小板和内皮细胞的脂质组成也受膳食脂肪酸的影响。这些变化会对细胞脂质和前列腺素代谢以及其他可能与血栓形成机制相关的细胞功能产生影响。高摄入饱和脂肪酸和n-9不饱和脂肪酸会导致血浆、血小板和内皮细胞发生变化，从而促进血栓形成和动脉粥样硬化。相比之下，n-6和n-3脂肪酸会使血浆脂蛋白和细胞脂质组成产生对抗动脉粥样硬化和血栓形成的作用。目前尚不清楚各种膳食脂肪酸之间的理想平衡状态。实验和流行病学研究支持低饱和脂肪摄入并补充n-6和n-3多不饱和脂肪酸的建议。
