Woodside Jayne V, McKinley Michelle C, Young Ian S
Nutrition and Metabolism Group, Centre for Clinical and Population Science, Queen's University Belfast, Lower Ground Floor, Pathology Building, Grosvenor Road, Belfast, BT12 6BJ, UK.
Curr Atheroscler Rep. 2008 Dec;10(6):460-6. doi: 10.1007/s11883-008-0072-5.
Dietary intake of both saturated and trans fatty acids has been associated with an increase in the risk of coronary heart disease (CHD). Evidence comes mainly from controlled dietary experiments with intermediate end points, such as blood lipoproteins, and from observational studies. A few small, randomized controlled trials with clinical end points have been carried out in which saturated fat was replaced with polyunsaturated fat, leading to a reduction in low-density lipoprotein cholesterol and a reduction in CHD risk. However, no such studies exist for trans fatty acids. More high-quality, randomized controlled trials on fatty acids and CHD are required, but public health recommendations to reduce intake of both saturated and trans fatty acids are appropriate based on the current evidence.
饱和脂肪酸和反式脂肪酸的膳食摄入都与冠心病（CHD）风险增加有关。证据主要来自以血脂蛋白等中间终点为指标的对照饮食实验以及观察性研究。已经开展了一些以临床终点为指标的小型随机对照试验，其中用多不饱和脂肪替代饱和脂肪，导致低密度脂蛋白胆固醇降低，冠心病风险也降低。然而，针对反式脂肪酸尚无此类研究。需要开展更多关于脂肪酸与冠心病的高质量随机对照试验，但基于目前的证据，减少饱和脂肪酸和反式脂肪酸摄入的公共卫生建议是恰当的。
