College of Pharmacy, Shenzhen Technology University, Shenzhen, 518118, People's Republic of China.
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.
Chem Biodivers. 2024 Nov;21(11):e202401027. doi: 10.1002/cbdv.202401027. Epub 2024 Sep 13.
Four new prenylated acetophenone derivatives, including one acetophenone dimer [acronyrone D (1)] and three acetophenone monomers [acronyrones E-G (2-4)], along with seven known analogues (5-11) were obtained from the leaves of Acronychia pedunculata. Their structures and absolute configurations were established by analysis of HRMS and NMR data, single crystal X-ray diffraction studies and quantum chemical calculations. In addition, the isolates were tested for their anti-proliferative acivity against HCT-116, RKO and SW480 cancer cell lines. Compound 5 exhibited significant anti-proliferative effects on the three cell lines, with IC values ranging from 0.24-5.3 μM.
从 Acronychia pedunculata 的叶子中分离得到了四个新的苯乙酮类衍生物，包括一个苯乙酮二聚体[acronyrone D（1）]和三个苯乙酮单体[acronyrones E-G（2-4）]，以及七个已知的类似物（5-11）。通过 HRMS 和 NMR 数据分析、单晶 X 射线衍射研究和量子化学计算确定了它们的结构和绝对构型。此外，对这些分离物进行了抗增殖活性测试，以评估它们对 HCT-116、RKO 和 SW480 癌细胞系的抑制作用。化合物 5 对这三个细胞系表现出显著的抗增殖作用，IC 值范围为 0.24-5.3 μM。
