Brain and Nerve Research Laboratory, Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Med Gas Res. 2024 Dec 1;14(4):192-200. doi: 10.4103/mgr.MEDGASRES-D-23-00006. Epub 2024 Mar 28.
Spinal cord injury (SCI) is a primary lesion of the spinal cord that results from external forces or diseases, accompanied by a cascade of secondary events. Nitric oxide, an endogenous gas that functions as a signaling molecule in the human body, plays a crucial role in vasodilation of smooth muscles, regulation of blood flow and pressure, and inflammatory response. This article provides a comprehensive overview of the involvement of nitric oxide in SCI and highlights recent advances in basic research on pharmacological agents that inhibit nitric oxide elevation after SCI, offering valuable insights for future therapeutic interventions targeting SCI.
脊髓损伤（SCI）是一种由外力或疾病引起的脊髓原发性损伤，伴有一系列的继发性事件。一氧化氮是一种内源性气体，在人体中作为信号分子发挥作用，在平滑肌扩张、血流和血压调节以及炎症反应中起着关键作用。本文全面概述了一氧化氮在 SCI 中的作用，并重点介绍了近年来抑制 SCI 后一氧化氮升高的药理学药物的基础研究进展，为针对 SCI 的未来治疗干预提供了有价值的见解。
