Gu Qiuyang, Yuan Shengye, An Yumei, Sun Wenyue, Xu Mingyuan, Xue Mengchun, Li Xianzhe, Liu Chao, Shan Haiyan, Zhang Mingyang
Department of Orthopedics, Suzhou BenQ Medical Center, Suzhou, Jiangsu Province, China.
Institute of Forensic Sciences, Suzhou Medical College, Suzhou, Jiangsu Province, China.
Neural Regen Res. 2026 Apr 1;21(4):1396-1408. doi: 10.4103/NRR.NRR-D-24-01029. Epub 2025 Mar 25.
Mitophagy is closely associated with the pathogenesis of secondary spinal cord injury. Abnormal mitophagy may contribute significantly to secondary spinal cord injury, leading to the impaired production of adenosine triphosphate, ion imbalance, the excessive production of reactive oxygen species, neuroinflammation, and neuronal cell death. Therefore, maintaining an appropriate balance of mitophagy is crucial when treating spinal cord injury, as both excessive and insufficient mitophagy can impede recovery. In this review, we summarize the pathological changes associated with spinal cord injury, the mechanisms of mitophagy, and the direct and indirect relationships between mitophagy and spinal cord injury. We also consider therapeutic approaches that target mitophagy for the treatment of spinal cord injury, including ongoing clinical trials and other innovative therapies, such as use of stem cells, nanomaterials, and small molecule polymers. Finally, we highlight the current challenges facing this field and suggest potential directions for future research. The aim of our review is to provide a theoretical reference for future studies targeting mitophagy in the treatment of spinal cord injury.
线粒体自噬与继发性脊髓损伤的发病机制密切相关。异常的线粒体自噬可能对继发性脊髓损伤有显著影响，导致三磷酸腺苷生成受损、离子失衡、活性氧过度产生、神经炎症和神经元细胞死亡。因此，在治疗脊髓损伤时，维持线粒体自噬的适当平衡至关重要，因为线粒体自噬过度和不足都会阻碍恢复。在本综述中，我们总结了与脊髓损伤相关的病理变化、线粒体自噬的机制，以及线粒体自噬与脊髓损伤之间的直接和间接关系。我们还考虑了针对线粒体自噬治疗脊髓损伤的方法，包括正在进行的临床试验和其他创新疗法，如使用干细胞、纳米材料和小分子聚合物。最后，我们强调了该领域目前面临的挑战，并提出了未来研究的潜在方向。我们综述的目的是为未来针对线粒体自噬治疗脊髓损伤的研究提供理论参考。
