Department of Physiology, School of Medicine, University of Galway, Galway, Ireland.
PLoS One. 2024 Jul 29;19(7):e0308099. doi: 10.1371/journal.pone.0308099. eCollection 2024.
There are very few studies concurrently evaluating the association between multiple physical activity (PA) domains and cancer prevalence. Therefore, this study aims to fill this gap by investigating the link between multiple PA subdomains [occupational PA (OPA), transportation-related PA (TPA), leisure-time PA (LTPA), and total PA] and the likelihood of cancer.
The data from National Health and Nutrition Examination Survey (NHANES) 2007-2008, 2009-2010, 2011-2012, 2013-2014, 2015-2016, and 2017-2018 were used in this study. Cancers are the primary outcome variable of interest in this study. PA was self- or proxy-reported using the Global Physical Activity Questionnaire (GPAQ). Multivariable logistic regression models were used, adjusted for covariates.
The trend analysis revealed that the prevalence of cancer statistically decreased with the increase in total PA amount. The participants achieving twice the minimum recommended PA guidelines (≥300 minutes) for total PA were 32% [0.68 (0.54, 0.86)] less likely to have cancer. However, significant associations between three PA subdomains (OPA, TPA, and LTPA) and cancers were not found in this study.
There is no significant association between any of these three single PA subdomains and cancer prevalence other than total PA. Therefore, this study recommends clinical practice should prioritize promoting comprehensive PA that integrates OPA, TPA, and LTPA to achieve at least 150 minutes per week (i.e. per seven days) initially and progressing towards 300 minutes for optimal cancer prevention.
很少有研究同时评估多个身体活动（PA）领域与癌症患病率之间的关系。因此，本研究旨在通过调查多个 PA 亚领域[职业 PA（OPA）、交通相关 PA（TPA）、休闲时间 PA（LTPA）和总 PA]与癌症发生可能性之间的联系来填补这一空白。
本研究使用了 2007-2008 年、2009-2010 年、2011-2012 年、2013-2014 年、2015-2016 年和 2017-2018 年国家健康和营养检查调查（NHANES）的数据。在这项研究中，癌症是主要关注的结果变量。PA 使用全球体力活动问卷（GPAQ）自我或代理报告。使用多变量逻辑回归模型，调整了协变量。
趋势分析表明，癌症的患病率随着总 PA 量的增加而呈统计学下降趋势。达到总 PA 最低推荐指南（≥300 分钟）两倍的参与者患癌症的可能性降低 32%[0.68（0.54，0.86)]。然而，本研究未发现三个 PA 亚领域（OPA、TPA 和 LTPA）与癌症之间存在显著关联。
除了总 PA 之外，这些三个单一 PA 亚领域中的任何一个与癌症患病率之间都没有显著关联。因此，本研究建议临床实践应优先促进综合 PA，将 OPA、TPA 和 LTPA 整合在一起，最初每周达到 150 分钟（即每周七天），并逐步达到 300 分钟，以达到最佳的癌症预防效果。
