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General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway.

作者信息

Liu Bin, Yi Dan, Xia Xiaomei, Ramirez Karina, Zhao Hanqiu, Cao Yanhong, Tripathi Ankit, Dong Ryan, Gao Anton, Ding Hongxu, Qiu Shenfeng, Kalinichenko Vladimir V, Zhao You-Yang, Fallon Michael B, Dai Zhiyu

机构信息

Division of Pulmonary, Critical Care and Sleep (B.L., D.Y., X.X., K.R., H.Z., Y.C., A.T., R.D., A.G., Z.D.), College of Medicine-Phoenix, University of Arizona.

Department of Internal Medicine (B.L., D.Y., X.X., K.R., H.Z., Y.C., A.T., R.D., A.G., M.B.F., Z.D.), College of Medicine-Phoenix, University of Arizona.

出版信息

Circulation. 2024 Jul 30;150(5):414-417. doi: 10.1161/CIRCULATIONAHA.123.067981. Epub 2024 Jul 29.

DOI:10.1161/CIRCULATIONAHA.123.067981
PMID:39074180
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11296501/
Abstract
摘要

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Generation of Plvap-CreER and Car4-CreER for genetic targeting of distinct lung capillary populations.生成用于不同肺毛细血管群体基因靶向的Plvap-CreER和Car4-CreER。
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小鼠肺组织的增强空间转录组学分析揭示了与肺动脉高压相关的细胞特异性基因表达变化。
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Application of Spatial Omics in the Cardiovascular System.空间组学在心血管系统中的应用。
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