Aksu Kurtuluş, Vural Solak Gürgün Tuğçe, Mutlu Levent Cem, Mutlu Pınar, Vayısoğlu Şahin Görkem, Erdem Türe Ezgi, Yormaz Burcu, Çapraz Aylin, Coşkun Beyan Ayşe, Solak Yavuzalp, Aksu Funda
Division of Immunology and Allergy, Department of Chest Diseases, University of Health Sciences Atatürk Sanatoryum Training and Research Hospital, Ankara, Turkey.
Department of Chest Diseases, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey.
J Aerosol Med Pulm Drug Deliv. 2024 Dec;37(6):346-350. doi: 10.1089/jamp.2024.0006. Epub 2024 Jul 30.
Asthma controller medications can be delivered via pressurized metered dose inhaler (pMDI) or dry powder inhaler (DPI) devices. This study aimed to evaluate the frequency of exacerbations and satisfaction rate with device use in asthmatics using pMDIs or DPIs. A multicenter, cross-sectional study was conducted in adults who used pMDIs or DPIs with correct inhaler technique and good adherence for asthma treatment. Demographic and asthma-related characteristics of the subjects and data regarding device satisfaction were collected through a face-to-face interview in the outpatient clinic. Rates of pMDI and DPI users and the data were compared between the two groups. The study included 338 patients (mean age: 48.6 ± 14.5 years, 253 [74.9%] women). Among participants, 96 (28.4%) were using pMDI and 242 (71.6%) were using DPI. The age of patients using pMDI were significantly lower compared with DPI users. No significant difference was observed in terms of device satisfaction and clinical outcomes of asthma between pMDI and DPI users with good inhaler technique and good adherence. More asthmatics use DPIs, however, pMDIs are used in younger asthmatic patients. No significant difference in terms of device satisfaction and clinical outcomes of asthma was observed between pMDI and DPI users.
哮喘控制药物可通过压力定量吸入器(pMDI)或干粉吸入器(DPI)装置给药。本研究旨在评估使用pMDI或DPI的哮喘患者的病情加重频率及对装置使用的满意度。对使用pMDI或DPI且吸入技术正确、哮喘治疗依从性良好的成年人进行了一项多中心横断面研究。通过门诊面对面访谈收集受试者的人口统计学和哮喘相关特征以及关于装置满意度的数据。比较两组中pMDI和DPI使用者的比例及数据。该研究纳入了338例患者(平均年龄:48.6±14.5岁,253例[74.9%]为女性)。参与者中,96例(28.4%)使用pMDI,242例(71.6%)使用DPI。使用pMDI的患者年龄显著低于使用DPI的患者。在吸入技术良好且依从性良好的pMDI和DPI使用者之间,在装置满意度和哮喘临床结局方面未观察到显著差异。然而,更多哮喘患者使用DPI,而pMDI用于较年轻的哮喘患者。pMDI和DPI使用者在装置满意度和哮喘临床结局方面未观察到显著差异。