新冠病毒相关心肌炎患者心脏激活成纤维细胞成像与磁共振成像的比较
Comparison of Cardiac Activated Fibroblast Imaging and Magnetic Resonance Imaging in Patients with COVID-19-Related Myocarditis.
作者信息
Su Yao, Liu Xin, Xie Boqia, Zhang Bowen, Yang Qi, Yang Min-Fu
机构信息
Department of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical University, 100020 Beijing, China.
Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, 100020 Beijing, China.
出版信息
Rev Cardiovasc Med. 2024 May 9;25(5):161. doi: 10.31083/j.rcm2505161. eCollection 2024 May.
BACKGROUND
This study aimed to explore the association between cardiac fibroblast activation and cardiac magnetic resonance (CMR) imaging parameters in patients with myocarditis following infection with coronavirus 2019 (COVID-19).
METHODS
In this prospective study, four patients with COVID-19-related myocarditis underwent Tc-labeled-hydrazinonicotinamide-fibroblast activation protein inhibitor-04 (Tc-HFAPi) single photon emission computed tomography/computed tomography (SPECT/CT) and CMR imaging. Segmental Tc-HFAPi activity was quantified as the percentage of average segmental myocardial count global left ventricular target-to-background ratio. T1/T2 values, extracellular volume (ECV), and late gadolinium enhancement (LGE) were analyzed by CMR. The consistency between myocardial Tc-HFAPi activity and CMR parameters was explored.
RESULTS
In patients with myocarditis, the proportion of segments with abnormal Tc-HFAPi activity was significantly higher than in those with abnormal LGE (81.25% vs. 60.93%, = 0.011), abnormal T2 (81.25% vs. 50.00%, 0.001), and abnormal ECV (81.25% vs. 59.38%, = 0.007); however, they were similar in those with abnormal native T1 (81.25% vs. 73.43%, = 0.291). Meanwhile, Tc-HFAPi imaging exhibited good consistency with native T1 (kappa = 0.69).
CONCLUSIONS
Increased cardiac Tc-HFAPi activity is present in COVID-19-related myocarditis, which is correlated with the native T1 values in CMR.
背景
本研究旨在探讨2019冠状病毒病（COVID-19）感染后心肌炎患者心脏成纤维细胞激活与心脏磁共振（CMR）成像参数之间的关联。
方法
在这项前瞻性研究中，4例COVID-19相关心肌炎患者接受了锝标记的肼基烟酰胺-成纤维细胞激活蛋白抑制剂-04（Tc-HFAPi）单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）和CMR成像。节段性Tc-HFAPi活性定量为平均节段心肌计数占整体左心室靶本底比值的百分比。通过CMR分析T1/T2值、细胞外容积（ECV）和延迟钆增强（LGE）。探讨心肌Tc-HFAPi活性与CMR参数之间的一致性。
结果
在心肌炎患者中，Tc-HFAPi活性异常节段的比例显著高于LGE异常者（81.25%对60.93%，P = 0.011）、T2异常者（81.25%对50.00%，P < 0.001）和ECV异常者（81.25%对59.38%，P = 0.007）；然而，在固有T1异常者中两者相似（81.25%对73.43%，P = 0.291）。同时，Tc-HFAPi成像与固有T1表现出良好的一致性（kappa = 0.69）。
结论
COVID-19相关心肌炎患者存在心脏Tc-HFAPi活性增加，这与CMR中的固有T1值相关。
Zotero 插件