Chu Danna, Wang Ruiling, Fan Zhen
School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, 200072 Shanghai, China.
Department of Oral Implantology, School & Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, 200072 Shanghai, China.
Rev Cardiovasc Med. 2023 Jul 13;24(7):200. doi: 10.31083/j.rcm2407200. eCollection 2023 Jul.
A potential relationship between oral inflammation and cardiovascular disease has been proposed; however, the impact of cardiovascular disease on implant restoration remains unclear. This systematic review aims to assess the relationship between peri-implantitis and cardiovascular disease based on review of data obtained through observational studies.
An extensive systematic literature search was performed using the PubMed/MEDLINE, Scopus, Web of Science and Cochrane Library databases. Studies published in English language up to June 2022 were conducted in accordance with PRISMA guidelines. These efforts identified 230 unique publications and, after selection, five studies were included in this meta-analysis. The Newcastle-Ottawa Scale table was used for literature quality assessment. A fixed-effect model was selected and RevMan software version 5.3 was used to identify the origin of the outcomes of the meta-analysis. Finally, results were reported through the PRISMA statement.
This meta-analysis found that in implant restoration the incidence of peri-implantitis in patients with cardiovascular disease was higher than those without cardiovascular disease (Risk ratio (RR) = 1.12; 95% CI: 1.02-1.23; z = 2.34; 0.05).
Based on current evidence, we conclude that the presence of cardiovascular disease increases the incidence of peri-implantitis.
PROSPERO database (CRD42022353693).
口腔炎症与心血管疾病之间的潜在关系已被提出；然而，心血管疾病对种植修复的影响仍不清楚。本系统评价旨在通过对观察性研究获得的数据进行综述，评估种植体周围炎与心血管疾病之间的关系。
使用PubMed/MEDLINE、Scopus、Web of Science和Cochrane图书馆数据库进行广泛的系统文献检索。截至2022年6月发表的英文研究均按照PRISMA指南进行。这些工作共确定了230篇独特的出版物，经过筛选，五项研究被纳入本荟萃分析。使用纽卡斯尔-渥太华量表表进行文献质量评估。选择固定效应模型，并使用RevMan 5.3软件确定荟萃分析结果的来源。最后，通过PRISMA声明报告结果。
本荟萃分析发现，在种植修复中，患有心血管疾病的患者种植体周围炎的发生率高于没有心血管疾病的患者（风险比（RR）=1.12；95%可信区间：1.02-1.23；z=2.34；P<0.05）。
基于目前的证据，我们得出结论，心血管疾病的存在会增加种植体周围炎的发生率。
PROSPERO数据库（CRD42022353693）。
