Orientation of One Health development: think globally and act locally.

One Health is dedicated to maintaining and fostering a dynamic balance among humans, animals, and the environment. Since 2013, it has seen considerable developments globally. This review aims to encapsulate the history of One Health, as well as chart its future trajectory. Numerous research institutions founded under the principles of One Health have been established, and several pragmatic projects are currently underway. While it is imperative to solidify foundational education, further policy support is required to cultivate the One Health paradigm. Identifying research directions at a political level is necessary to provide the technical support needed for practical application. The future of One Health envisions a comprehensive approach to primary prevention, the utilization of open and shared data sets, as well as real-world surveys and interviews. This integrated approach is encapsulated in the concept of One Health Delivery. At this stage, One Health Delivery needs to build a systematic framework that focuses on integrating and communicating across disciplines and training researchers with complete practical skills.