Gao Zhen, Zhou Fan, Mu Junsheng
Department of Cardiac Surgery, Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Diseases, 100029 Beijing, China.
Department of Ultrasound, The Third Medical Center of PLA General Hospital, 100039 Beijing, China.
Rev Cardiovasc Med. 2023 Feb 24;24(3):69. doi: 10.31083/j.rcm2403069. eCollection 2023 Mar.
The incidence of cardiovascular disease has been continuously increasing. Because cardiomyocytes (CM) are non-renewable cells, it is difficult to find appropriate CM sources to repair injured hearts. Research of human induced pluripotent stem cell (hiPSC) differentiation and maturation into CM has been invaluable for the treatment of heart diseases. The use of hiPSCs as regenerative therapy allows for the treatment of many diseases that cannot be cured, including progressive heart failure. This review contributes to the study of cardiac repair and targeted treatment of cardiovascular diseases at the cytological level. Recent studies have shown that for differentiation and maturation of hiPSCs into CMs, fatty acids have a strong influence on cellular metabolism, organelle development, expression of specific genes, and functional performance. This review describes the recent research progress on how fatty acids affect the differentiation of hiPSCs into CMs and their maturation.
心血管疾病的发病率一直在持续上升。由于心肌细胞（CM）是不可再生细胞，因此很难找到合适的CM来源来修复受损心脏。人类诱导多能干细胞（hiPSC）分化并成熟为CM的研究对于心脏病的治疗具有重要价值。将hiPSC用作再生疗法能够治疗许多无法治愈的疾病，包括进行性心力衰竭。本综述有助于在细胞学水平上研究心脏修复和心血管疾病的靶向治疗。最近的研究表明，对于hiPSC分化并成熟为CM的过程，脂肪酸对细胞代谢、细胞器发育、特定基因的表达以及功能表现都有强烈影响。本综述描述了脂肪酸如何影响hiPSC向CM分化及其成熟的最新研究进展。
