Kobbe Robin, Rau Cornelius, Schulze-Sturm Ulf, Stahl Felix, Fonseca-Brito Luis, Diemert Anke, Lütgehetmann Marc, Addo Marylyn M, Arck Petra, Weskamm Leonie M
From the Institute for Infection Research and Vaccine Development.
Department of Infectious Disease Epidemiology.
Pediatr Infect Dis J. 2024 Jul 30;43(12):1200-3. doi: 10.1097/INF.0000000000004488.
Humoral immune responses after BNT162b2 vaccination are predominantly composed of immunoglobulin (Ig) G1 and IgG3 subclass antibodies. As previously described in adults, S1-specific and receptor-binding domain-specific IgG4 levels increase significantly 1 year after the second BNT162b2 vaccination in children 5-11 years of age. Understanding mRNA vaccine-specific IgG4 responses in all age groups is crucial as more mRNA vaccines will reach licensure in the coming years.
BNT162b2疫苗接种后的体液免疫反应主要由免疫球蛋白（Ig）G1和IgG3亚类抗体组成。如先前在成人中所描述的，在5至11岁儿童中，第二次接种BNT162b2疫苗1年后，S1特异性和受体结合域特异性IgG4水平显著升高。随着未来几年更多的mRNA疫苗获得许可，了解所有年龄组中mRNA疫苗特异性IgG4反应至关重要。
