Center for Arctic Health and Molecular Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland.
Sci Rep. 2021 Nov 12;11(1):22182. doi: 10.1038/s41598-021-01580-0.
High levels of persistent organic pollutants (POPs) and heavy metals are found in Arctic populations. POP and heavy metals are linked to impaired cognitive development. This study examined associations between prenatal POP and metals exposure and problematic child behavior using the Strength and Difficulties Questionnaire (SDQ). POPs and metals were measured in 102 pregnant Greenlandic women. During follow-up at 3-5 years, parents answered an assisted questionnaire including children's SDQ scores. Associations were analyzed using linear and logistic regression analyses and adjusted for maternal plasma cotinine, educational level and age at delivery. In the adjusted analyses, the medium tertile of hexachlorobenzene (β = 3.06, p = 0.010), β-hexachlorocyclohexane (β = 3.58, p = 0.004) and trans-nonachlor (β = 2.06, p = 0.082) were positively associated with SDQ scores. The continuous cis-nonachlor (OR = 1.09, p = 0.079), dichloro-diphenyl-dichloroethylene (OR = 1.01, p = 0.077), trans-nonachlor (OR = 1.01, p = 0.091), and sum Organochlorine-Pesticides (OR = 1.00, p = 0.094) were positively associated with abnormal SDQ score and the continuous mirex (OR = 1.28, p = 0.096), oxychlordane (OR = 1.04, p = 0.066), and trans-nonachlor (OR = 1.02, p = 0.071) with abnormal hyperactivity score. We found no consistent evidence of associations between polychlorinated biphenyls, perfluoroalkylated substances and heavy metals and problematic behavior. Prenatal organochlorine pesticide exposure associated significantly with problematic behavior in 3-5 year old children.
北极地区的人群体内存在高水平的持久性有机污染物（POPs）和重金属。POP 和重金属与认知发育受损有关。本研究使用《长处与困难问卷》（SDQ）检查了产前 POP 和金属暴露与儿童行为问题之间的关联。在 102 名格陵兰孕妇中测量了 POPs 和金属。在 3-5 岁的随访期间，父母回答了一份辅助问卷，其中包括孩子的 SDQ 评分。使用线性和逻辑回归分析进行关联分析，并根据母体血浆可替宁、教育水平和分娩年龄进行调整。在调整分析中，六氯苯的中 tertile（β=3.06，p=0.010）、β-六氯环己烷（β=3.58，p=0.004）和反式-十氯酮（β=2.06，p=0.082）与 SDQ 评分呈正相关。连续 cis-十氯酮（OR=1.09，p=0.079）、二氯二苯二氯乙烯（OR=1.01，p=0.077）、反式-十氯酮（OR=1.01，p=0.091）和有机氯农药总量（OR=1.00，p=0.094）与异常 SDQ 评分呈正相关，连续灭蚁灵（OR=1.28，p=0.096）、氧氯丹（OR=1.04，p=0.066）和反式-十氯酮（OR=1.02，p=0.071）与异常多动评分呈正相关。我们没有发现多氯联苯、全氟烷基物质和重金属与行为问题之间存在一致关联的证据。产前有机氯农药暴露与 3-5 岁儿童的行为问题显著相关。
