Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Box 980126, Richmond, VA 23298-0126, USA.
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Box 980126, Richmond, VA 23298-0126, USA.
Gen Hosp Psychiatry. 2024 Sep-Oct;90:91-98. doi: 10.1016/j.genhosppsych.2024.07.013. Epub 2024 Jul 26.
In the current exploratory study we estimate comorbidity rates between FDs [fibromyalgia (FM), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and irritable bowel syndrome (IBS)]-and IDs-[major depressive disorder (MDD) and generalized anxiety disorder (GAD)] by using self-reported diagnostic criteria.
We analyzed data from 107,849 participants (mean age = 49.3 (SD = 13.0), 58.6% women) of the Lifelines Cohort Study. Lifelines is a prospective population-based cohort study in the northeast of the Netherlands. Current IDs were assessed using the Mini-International Neuropsychiatric Interview. Current FM, ME/CFS, and IBS were assessed according to the 2010 American College of Rheumatology criteria, the 1994 Centers for Disease Control and Prevention criteria and the ROME IV criteria, respectively. We estimated tetrachoric correlations between diagnoses and tested for sex differences. Additionally, we estimated the ratio of observed-to-expected frequency for combinations of diagnoses.
FDs and IDs are highly comorbid (odds ratios: 3.2-12.6) with associations stronger among men. Participants with at least three disorders/diagnoses were more prevalent than expected by chance.
Studies that aim to explain sex differences and the comorbidity of specific combinations of IDs and FDs will be an important contribution to understanding the etiology of these conditions.
在当前的探索性研究中，我们使用自我报告的诊断标准来估计 FD [纤维肌痛 (FM)、慢性疲劳综合征/肌痛性脑脊髓炎 (ME/CFS) 和肠易激综合征 (IBS)] 和 ID [重度抑郁症 (MDD) 和广泛性焦虑症 (GAD)] 之间的共病率。
我们分析了 Lifelines 队列研究 107849 名参与者（平均年龄 49.3（SD 13.0），58.6%为女性）的数据。Lifelines 是荷兰东北部的一项前瞻性人群队列研究。目前的 ID 使用 Mini-International Neuropsychiatric Interview 进行评估。目前的 FM、ME/CFS 和 IBS 根据 2010 年美国风湿病学会标准、1994 年疾病控制和预防中心标准和 ROME IV 标准进行评估。我们估计了诊断之间的 tetrachoric 相关性，并测试了性别差异。此外，我们还估计了观察到的诊断组合与预期频率的比值。
FD 和 ID 高度共病（比值比：3.2-12.6），男性之间的关联更强。至少有三种疾病/诊断的参与者比预期更常见。
旨在解释 ID 和 FD 特定组合的性别差异和共病性的研究将对理解这些疾病的病因做出重要贡献。
