Szewczyk Anna K, Skrobas Urszula, Jamroz-Wiśniewska Anna, Mitosek-Szewczyk Krystyna, Rejdak Konrad
Department of Neurology, Medical University of Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland.
Department of Child Neurology, Medical University of Lublin, ul. Profesora Antoniego Gębali 6, 20-093 Lublin, Poland.
Healthcare (Basel). 2021 Nov 2;9(11):1492. doi: 10.3390/healthcare9111492.
Since the outbreak of the new coronavirus, healthcare systems around the world have witnessed not only COVID-19 symptoms but also long-term complications of the aforementioned, including neurological problems. We report a clinical case of an adult patient with bilateral facial nerve palsy and progressive ascending paresis of the limbs after contracting the novel coronavirus (COVID-19). Additionally, the systematic review aimed to identify and summarize specific clinical features, outcomes and complications of the studies focusing on bilateral facial diplegia as a sequela of COVID-19 infection. The total number of analyzed patients was 15. Only one patient was diagnosed with isolated bilateral palsy; the rest had Guillain-Barré Syndrome (GBS). With one exception, all the presented cases had favorable outcomes, with facial palsy recovery from slight to almost complete. In patients with a confirmed COVID-19 diagnosis, bilateral facial palsy may be an isolated symptom as well as a variant of GBS. Symptoms of cranial nerve damage during a COVID-19 infection may explain the appearance of facial nerve damage. In order to clarify the spectrum of neurological manifestations and a causal relation between SARS-CoV-2, COVID-19 vaccination and neurological symptoms, direct attention towards the study of this virus is crucial. It seems reasonable to recognize human coronavirus as another potential GBS trigger.
自新型冠状病毒爆发以来，世界各地的医疗系统不仅见证了新冠病毒感染症状，还见证了上述症状的长期并发症，包括神经问题。我们报告了一例成年患者的临床病例，该患者在感染新型冠状病毒（COVID-19）后出现双侧面神经麻痹和四肢进行性上升性麻痹。此外，该系统评价旨在识别和总结以双侧面瘫作为COVID-19感染后遗症的研究的具体临床特征、结局和并发症。分析的患者总数为15例。仅1例患者被诊断为孤立性双侧麻痹；其余患者患有吉兰-巴雷综合征（GBS）。除1例例外，所有报告的病例预后良好，面瘫从轻微恢复到几乎完全恢复。在确诊为COVID-19的患者中，双侧面瘫可能是一种孤立症状，也可能是GBS的一种变体。COVID-19感染期间的颅神经损伤症状可能解释了面神经损伤的出现。为了阐明神经表现谱以及严重急性呼吸综合征冠状病毒2（SARS-CoV-2）、COVID-19疫苗接种与神经症状之间的因果关系，直接关注对这种病毒的研究至关重要。将人类冠状病毒视为另一种潜在的GBS触发因素似乎是合理的。
