Vafaeimanesh Jamshid, Bagherzadeh Mohammad, Mirzaei Atefeh, Parham Mahmoud, Norouzinia Mohsen, Vafaee Reza
Gastrointestinal and Liver Disease Research Center, Iran University of Medical Science, Tehran, Iran; Qom Gastroenterology and Hepatlogy Research Center, Qom University of Medical Sciences, Qom, Iran.
Qom Gastroenterology and Hepatlogy Research Center, Qom University of Medical Sciences, Qom, Iran.
Gastroenterol Hepatol Bed Bench. 2016 Dec;9(Suppl1):S36-S41.
The aim of this study is to survey the effect of Helicobacter Pylori on metabolic syndrome parameters in diabetic patients.
Helicobacter pylori () infection is the most common infection in developing countries. Some studies showed the association between infection and insulin resistance. Insulin resistance is a major mechanism in the development of metabolic syndrome (MetS) and it is said that MetS is more prevalent among HP infected subjects. Also, some studies have shown that MetS is common among patients with type 2 diabetes mellitus. In this study, we aimed to investigate the prevalence of MetS in diabetic patients and its association with .
This cross-sectional study was carried out from May to December 2014 on 211 diabetic patients. For each patient, the following data were collected: age, gender, diabetes duration, weight, body mass index (BMI), waist circumference, blood pressure (BP), HDL, cholesterol, triglyceride (TG), total cholesterol, and HbA1c. The lipid profile was performed on fasting samples. Anti- HP IgG antibody was measured and serum titer >30AU/mL was considered positive. MetS was diagnosed by The National Cholesterol Education Program's Adult Treatment Panel III report (NCEP-ATPIII) and IDF criteria.
Totally 139 patients (65.9%) were HP+ and 72 patients (34.1%) were HP-. Age, gender and diabetes duration were not significantly different in both groups. BMI was significantly lower in HP+ women (29.05±5.26 vs. 31.45±4.8, p=0.02). Although the waist circumference of men was not different between the two groups but it was significantly lower in HP+ women (102.04±12.37 vs. 97.3±10, p=0.03). Although BP and TG levels were not statistically different in HP+ and HP- patients, but HP+ patients had lower HDL level (p=0.037) which was due to lower HDL in men (58.2±26.6 vs. 72.48±28.1, p=0.012). The prevalence of MetS according to the IDF criteria among HP+ and HP- patients was 76.6% vs. 69.8% (p=0.27). Also, the prevalence of MetS according to NCEP-ATP III criteria among HP+ and HP- patients was 90.4% vs. 87.2% (p=0.5). Duration of diabetes did not affect the prevalence of metabolic syndrome among HP+ and HP- patients.
It seems that HP infection increases the prevalence of metabolic syndrome through an increase in insulin resistance. According to NCEP-ATPIII criteria, the increase in the prevalence of metabolic syndrome in HP+ patients is almost significant, however more complete studies is recommended to investigate this relationship.
本研究旨在调查幽门螺杆菌对糖尿病患者代谢综合征参数的影响。
幽门螺杆菌（Hp）感染是发展中国家最常见的感染。一些研究显示了Hp感染与胰岛素抵抗之间的关联。胰岛素抵抗是代谢综合征（MetS）发生发展的主要机制，据说MetS在Hp感染人群中更为普遍。此外，一些研究表明MetS在2型糖尿病患者中很常见。在本研究中，我们旨在调查糖尿病患者中MetS的患病率及其与Hp的关联。
这项横断面研究于2014年5月至12月对211名糖尿病患者进行。为每位患者收集以下数据：年龄、性别、糖尿病病程、体重、体重指数（BMI）、腰围、血压（BP）、高密度脂蛋白（HDL）、胆固醇、甘油三酯（TG）、总胆固醇和糖化血红蛋白（HbA1c）。血脂谱检测采用空腹样本。检测抗Hp IgG抗体，血清滴度>30AU/mL被视为阳性。根据美国国家胆固醇教育计划成人治疗小组第三次报告（NCEP-ATPIII）和国际糖尿病联盟（IDF）标准诊断MetS。
共有139例患者（65.9%）为Hp阳性，72例患者（34.1%）为Hp阴性。两组患者的年龄、性别和糖尿病病程无显著差异。Hp阳性女性的BMI显著较低（29.05±5.26 vs. 31.45±4.8，p=0.02）。虽然两组男性的腰围没有差异，但Hp阳性女性的腰围显著较低（102.04±12.37 vs. 97.3±10，p=百分之0.03）。虽然Hp阳性和Hp阴性患者的血压和TG水平无统计学差异，但Hp阳性患者的HDL水平较低（p=0.037），这是由于男性HDL较低（58.2±26.6 vs. 72.48±28.1，p=0.012）。根据IDF标准，Hp阳性和Hp阴性患者中MetS的患病率分别为76.6%和6百分之9.8（p=0.27）。此外，根据NCEP-ATP III标准，Hp阳性和Hp阴性患者中MetS的患病率分别为90.4%和87.2%（p=0.5）。糖尿病病程对Hp阳性和Hp阴性患者中代谢综合征的患病率没有影响。
似乎Hp感染通过增加胰岛素抵抗来增加代谢综合征的患病率。根据NCEP-ATPIII标准，Hp阳性患者中代谢综合征患病率的增加几乎具有显著性，然而建议进行更全面的研究来调查这种关系。
