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外泌体在炎症性疾病中作为治疗生物标志物的诊断作用日益增强。

The Increasing Diagnostic Role of Exosomes in Inflammatory Diseases to Leverage the Therapeutic Biomarkers.

作者信息

Wang Yan, Ma Hui, Zhang Xiaohua, Xiao Xia, Yang Zecheng

机构信息

Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, 130000, People's Republic of China.

Department of Gastrointestinal Surgery, The Second Hospital of Jilin University, Changchun, 130000, People's Republic of China.

出版信息

J Inflamm Res. 2024 Jul 25;17:5005-5024. doi: 10.2147/JIR.S475102. eCollection 2024.

Abstract

Inflammatory diseases provide substantial worldwide concerns, affecting millions of people and healthcare systems by causing ongoing discomfort, diminished quality of life, and increased expenses. In light of the progress made in treatments, the limited effectiveness and negative side effects of present pharmaceuticals need a more comprehensive comprehension of the underlying processes in order to develop more precise remedies. Exosomes, which are tiny vesicles that play a vital role in cell communication, have been identified as prospective vehicles for effective delivery of anti-inflammatory medicines, immunomodulators, and gene treatments. Vesicles, which are secreted by different cells, have a crucial function in communicating between cells. This makes them valuable in the fields of diagnostics and therapies, particularly for inflammatory conditions. Exosomes have a role in regulating the immune system, transporting cytokines, and influencing cell signaling pathways associated with inflammation. They consist of proteins, lipids, and genetic information that have an impact on immune responses and inflammation. Scientists are now investigating exosomes as biomarkers for inflammatory disease. This review article aims to develop non-invasive diagnostic techniques with improved sensitivity and specificity. Purpose of this review is a thorough examination of exosomes in pharmacology, specifically emphasizing their origin, contents, and functions, with the objective of enhancing diagnostic and therapeutic strategies for inflammatory conditions. Gaining a comprehensive understanding of the intricate mechanisms involved in exosome-mediated interactions and their impact on immune responses is of utmost importance in order to devise novel approaches for tackling inflammatory disease and enhancing patient care.

摘要

炎症性疾病在全球范围内引起了广泛关注,它影响着数百万人以及医疗保健系统,导致持续不适、生活质量下降和费用增加。鉴于治疗方面取得的进展,目前药物的有限疗效和负面副作用需要更全面地理解其潜在机制,以便开发更精确的治疗方法。外泌体是在细胞通讯中起关键作用的微小囊泡,已被确定为有效递送抗炎药物、免疫调节剂和基因治疗的潜在载体。由不同细胞分泌的囊泡在细胞间通讯中具有关键作用。这使得它们在诊断和治疗领域具有重要价值,特别是对于炎症性疾病。外泌体在调节免疫系统、运输细胞因子以及影响与炎症相关的细胞信号通路方面发挥作用。它们由对免疫反应和炎症有影响的蛋白质、脂质和遗传信息组成。科学家们目前正在研究将外泌体作为炎症性疾病的生物标志物。这篇综述文章旨在开发具有更高灵敏度和特异性的非侵入性诊断技术。本综述的目的是全面审视外泌体在药理学中的作用,特别强调其起源、内容物和功能,以期加强针对炎症性疾病的诊断和治疗策略。为了设计出应对炎症性疾病和改善患者护理的新方法,全面了解外泌体介导的相互作用所涉及的复杂机制及其对免疫反应的影响至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55e9/11287202/ea26c295c8ae/JIR-17-5005-g0001.jpg

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