College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, People's Republic of China.
College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, People's Republic of China.
Pathol Res Pract. 2023 Feb;242:154332. doi: 10.1016/j.prp.2023.154332. Epub 2023 Jan 21.
Rheumatoid arthritis (RA) is a chronic degenerative disease characterized by persistent systemic synovitis, with a high risk of stiffness, pain, and swelling. It may affect the other extra-articular tissues. There is no ideal treatment for this disease at present, and it can only be controlled by medication to alleviate the prognosis. Exosomes are small vesicles secreted by various cells in the organism under normal or pathological conditions, and play a role in immune response, antigen presentation, cell migration, cell differentiation, tumor invasion and so on. Due to the adverse effects of conventional drugs and treatments in the treatment of RA, exosomes, as a nanocarrier with many advantages, can have a great impact on the loading of drugs for the treatment of RA. This article reviews the role of exosomes in the pathogenesis of RA and the progress of exosome-based therapy for RA.
类风湿关节炎（RA）是一种慢性退行性疾病，以持续的全身滑膜炎为特征，存在僵硬、疼痛和肿胀的高风险。它可能会影响其他关节外组织。目前针对这种疾病还没有理想的治疗方法，只能通过药物控制来缓解预后。外泌体是在正常或病理条件下，由机体各种细胞分泌的小囊泡，在免疫应答、抗原呈递、细胞迁移、细胞分化、肿瘤侵袭等方面发挥作用。由于常规药物和治疗方法在 RA 治疗中的不良反应，外泌体作为一种具有许多优点的纳米载体，可以对治疗 RA 的药物载药产生很大的影响。本文综述了外泌体在 RA 发病机制中的作用及基于外泌体的 RA 治疗进展。
