Saleem Mavra, Shahzad Khawar Ali, Marryum Munazzah, Singh Shekhar, Zhou Quan, Du Siting, Wang Shuanghu, Shao Chuxiao, Shaikh Imran Ibrahim
Department of Zoology, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
Department of ORL-HNS, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Stem Cell Res Ther. 2024 Dec 18;15(1):477. doi: 10.1186/s13287-024-04107-2.
Exosomes, small extracellular vesicles secreted by cells, have emerged as focal mediators in intercellular communication and therapeutic interventions across diverse biomedical fields. Inflammatory disorders, including inflammatory bowel disease, acute liver injury, lung injury, neuroinflammation, and myocardial infarction, are complex conditions that require innovative therapeutic approaches. This review summarizes recent advances in exosome-based therapies for inflammatory disorders, highlighting their potential as diagnostic biomarkers and therapeutic agents. Exosomes have shown promise in reducing inflammation, promoting tissue repair, and improving functional outcomes in preclinical models of inflammatory disorders. However, further research is needed to overcome the challenges associated with exosome isolation, characterization, and delivery, as well as to fully understand their mechanisms of action. Current limitations and future directions in exosome research underscore the need for enhanced isolation techniques and deeper mechanistic insights to harness exosomes' full therapeutic potential in clinical applications. Despite these challenges, exosome-based therapies hold great potential for the treatment of inflammatory disorders and may offer a new paradigm for personalized medication.
外泌体是细胞分泌的小细胞外囊泡，已成为跨多种生物医学领域的细胞间通讯和治疗干预的关键介质。包括炎症性肠病、急性肝损伤、肺损伤、神经炎症和心肌梗死在内的炎症性疾病是复杂的病症，需要创新的治疗方法。本综述总结了基于外泌体的炎症性疾病治疗的最新进展，强调了它们作为诊断生物标志物和治疗剂的潜力。在外泌体在炎症性疾病的临床前模型中显示出在减轻炎症、促进组织修复和改善功能结果方面的前景。然而，需要进一步研究以克服与外泌体分离、表征和递送相关的挑战，以及充分了解其作用机制。外泌体研究的当前局限性和未来方向强调了需要改进分离技术并深入了解作用机制，以充分发挥外泌体在临床应用中的全部治疗潜力。尽管存在这些挑战，基于外泌体的疗法在治疗炎症性疾病方面具有巨大潜力，并可能为个性化药物治疗提供新的范例。
