Precision Medicine Translational Research Center (PMTRC), West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
J Mater Chem B. 2024 Sep 11;12(35):8523-8542. doi: 10.1039/d4tb00719k.
The ion-sensitive field effect transistor (ISFET) has emerged as a crucial sensor device, owing to its numerous benefits such as label-free operation, miniaturization, high sensitivity, and rapid response time. Currently, ISFET technology excels in detecting ions, nucleic acids, proteins, and cellular components, with widespread applications in early disease screening, condition monitoring, and drug analysis. Recent advancements in sensing techniques, coupled with breakthroughs in nanomaterials and microelectronics, have significantly improved sensor performance. These developments are steering ISFETs toward a promising future characterized by enhanced sensitivity, seamless integration, and multifaceted detection capabilities. This review explores the structure and operational principles of ISFETs, highlighting recent research in ISFET biosensors for biomarker detection. It also examines the limitations of these sensors, proposes potential solutions, and anticipates their future trajectory. This review aims to provide a valuable reference for advancing ISFETs in the field of biomarker measurement.
离子敏场效应晶体管（ISFET）因其无标记操作、小型化、高灵敏度和快速响应时间等诸多优点，已成为一种至关重要的传感器设备。目前，ISFET 技术在检测离子、核酸、蛋白质和细胞成分方面表现出色，在早期疾病筛查、状态监测和药物分析等领域得到了广泛应用。近年来，传感技术的进步，加上纳米材料和微电子学的突破，显著提高了传感器的性能。这些发展使 ISFET 朝着具有更高灵敏度、无缝集成和多方面检测能力的有前途的未来发展。本文综述了 ISFET 的结构和工作原理，重点介绍了用于生物标志物检测的 ISFET 生物传感器的最新研究进展。还检查了这些传感器的局限性，提出了潜在的解决方案，并预测了它们的未来发展方向。本文旨在为推进生物标志物测量领域的 ISFET 提供有价值的参考。
