Rahimi-Dehkordi Nasim, Heidari-Soureshjani Saeid, Rostamian Sahar
Department of Pediatrics, School of Medicine, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Cent Nerv Syst Agents Med Chem. 2025;25(2):143-156. doi: 10.2174/0118715249297934240630111059.
Seizures due to epilepsy in any form cause a wide range of problems in a patient's physical, psychological, and social health. This study aimed to investigate piperine's anti-seizure and antiepileptic effects and mechanisms.
In this systematic review study, which was conducted according to the principles of PRISMA 2020, the initial search was conducted on November 2, 2023, using EndNote software. Various databases such as PubMed, Cochrane Library, Web of Science, Embase, and Scopus were searched using specific keywords. After screening the articles, a form was designed according to the objectives of the study, and the information related to the included articles was entered in the form, and the studies were reviewed.
Piperine showed its antiepileptic activity by affecting the brain's antioxidant, anti-inflammatory, and anti-apoptotic activity. It also, by modulating brain-derived neurotrophic factor (BDNF) and gamma-aminobutyric acid (GABA)ergic activity, can control seizures. In addition, piperine can help treat seizures and epilepsy by elevating 5-HT levels in the brain, modulating astrocyte and microglia function, modulatory effects on Ca and NA channels, increasing antiepileptic drugs bioavailability and influencing protein and gene expression.
and studies showed beneficial effects on treating epilepsy. Although clinical studies also showed similar results, these needed to be increased, and more clinical studies needed to be designed in this field.
任何形式的癫痫发作都会给患者的身体、心理和社会健康带来一系列问题。本研究旨在探讨胡椒碱的抗惊厥和抗癫痫作用及机制。
在这项根据PRISMA 2020原则进行的系统评价研究中，于2023年11月2日使用EndNote软件进行了初步检索。使用特定关键词搜索了各种数据库，如PubMed、Cochrane图书馆、科学网、Embase和Scopus。筛选文章后，根据研究目的设计了一种表格，并将纳入文章的相关信息填入表格中，然后对研究进行了综述。
胡椒碱通过影响大脑的抗氧化、抗炎和抗凋亡活性表现出其抗癫痫活性。它还通过调节脑源性神经营养因子（BDNF）和γ-氨基丁酸（GABA）能活性来控制癫痫发作。此外，胡椒碱可以通过提高大脑中的5-羟色胺水平、调节星形胶质细胞和小胶质细胞功能、对钙和钠通道的调节作用、提高抗癫痫药物的生物利用度以及影响蛋白质和基因表达来帮助治疗癫痫发作和癫痫。
多项研究表明其对治疗癫痫有益。尽管临床研究也显示了类似的结果，但这些研究需要增加，并且该领域需要设计更多的临床研究。
