Li Shaochen, Lv Min, Xu Hui
School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang Province, P. R. China.
College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, P. R. China.
Mini Rev Med Chem. 2023;23(8):917-940. doi: 10.2174/1389557522666220726121012.
Natural products are an invaluable source for the discovery of drug and pesticide candidates. Piperine, a simple and pungent alkaloid, is isolated from several plants of Piperaceae. Piperine and its derivatives displayed a wide range of biological properties, such as antitumor activity, anti-inflammatory activity, antioxidant activity, neuroprotective activity, insecticidal activity, etc. In recent years, lots of works focused on the biological activities, mechanisms of action, total synthesis, and structural modifications of piperine and its derivatives have been conducted. To the best of our knowledge, however, few review articles related to the biological activities, mechanisms of action, total synthesis, and structural modifications of piperine and its derivatives have been reported to date. Therefore, this review summarizes the research advances (from 2014 to 2020) of piperine and its derivatives regarding bioactivity, mechanisms of action, total synthesis, and structural modifications. Meanwhile, the structure-activity relationships of piperine and its derivatives are also discussed.
天然产物是发现药物和农药候选物的宝贵来源。胡椒碱是一种简单而辛辣的生物碱，从胡椒科的几种植物中分离得到。胡椒碱及其衍生物具有广泛的生物学特性，如抗肿瘤活性、抗炎活性、抗氧化活性、神经保护活性、杀虫活性等。近年来，针对胡椒碱及其衍生物的生物学活性、作用机制、全合成及结构修饰开展了大量研究工作。然而，据我们所知，迄今为止，很少有关于胡椒碱及其衍生物的生物学活性、作用机制、全合成及结构修饰的综述文章报道。因此，本综述总结了（2014年至2020年）胡椒碱及其衍生物在生物活性、作用机制、全合成及结构修饰方面的研究进展。同时，还讨论了胡椒碱及其衍生物的构效关系。
